Preview

Elephant Genes Hold Cancer-Fighting Secret By Laura Geggel: Article Analysis

Satisfactory Essays
Open Document
Open Document
382 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Elephant Genes Hold Cancer-Fighting Secret By Laura Geggel: Article Analysis
In the article, “Elephant Genes Hold Cancer-Fighting Secret,” the author, Laura Geggel, explains how researchers have recently discovered that cancer is less common in elephants than in humans because they have more copies of a gene that stops tumor growth. Researchers that understand how this gene has evolved and why it works to stop cancer growth in elephants may be able help find ways to treat or cure cancer in humans. Researchers conducted a study that focused mainly on the TP53 gene, which normally codes for a protein that stops tumor growth. In many human cancers, this gene is mutated and unable to do its job, which allows increased cell reproduction and genomic instability. Humans inherit one copy of TP53 from each of their parents and

You May Also Find These Documents Helpful

  • Good Essays

    Tumor Suppressor genes - They specify proteins that directly and indirectly inhibit the cell cycle…

    • 352 Words
    • 2 Pages
    Good Essays
  • Better Essays

    Edexcel Biology Unit 5 Q&A

    • 1950 Words
    • 8 Pages

    Give one reason why it is expected that long-lived animals are likely to develop cancer, as opposed to shorter-lived animals. [Paragraph 21] (1)…

    • 1950 Words
    • 8 Pages
    Better Essays
  • Satisfactory Essays

    Gene Report 3

    • 488 Words
    • 4 Pages

    - IL2RG can cause X-linked severe immunodeficiency (XSCID) as well as Xlinked combined immunodeficiency (XCID).…

    • 488 Words
    • 4 Pages
    Satisfactory Essays
  • Satisfactory Essays

    Bad Luck Cancer Case

    • 266 Words
    • 2 Pages

    It was long believed that the occurrence of cancer is owed to genetic inheritance, unhealthy environment and, poor lifestyle choices, such as improper diet, use of tobacco and a lack of physical activity. However, a new study made by American scientists found out that these factors do not necessarily have an impact on this disease. Instead, the people who suffer from a cancerous disease simply don’t have much luck.…

    • 266 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    Anatomy Pictures

    • 598 Words
    • 3 Pages

    cancer is two to three times greater than an average person. But risk is still small, and a lot of the times, the gene will not even be found. Basically, anyone can develop mutated genes from the…

    • 598 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Glioblastoma Essay

    • 1017 Words
    • 5 Pages

    research have shown that in several forms of are human cancers, only a minority subpopulation…

    • 1017 Words
    • 5 Pages
    Good Essays
  • Better Essays

    Cancer is a dangerous disease that is caused by an uncontrolled group of abnormal cells in the body. Cancerous cells, also known as malignant tumors or neoplasm, begin to divide without stopping and invade surrounding tissues. The body is made up of trillions of cells, which means cancer can start from almost anywhere in the body. Human cells grow and divide to form new cells continuously. When cells grow old or become damaged they die and new cells are formed to take their place. This process is not the same when cancer starts to develop. As cells become more and more abnormal, old, or damaged instead of dying, they survive and these mutated cells no longer exhibit their original behavior. These new cells have the ability to divide without…

    • 1969 Words
    • 8 Pages
    Better Essays
  • Better Essays

    According to (Cancer.net, 2011) “Many cancers begin when one or more genes in a cell are mutated (changed), creating and abnormal protein or no protein at all. The information provided by an abnormal protein is different from that of a normal protein, which can cause cells to multiply uncontrollable and become cancerous.” The changes in protein are the identifying factors that give researcher the signs that cancer in fact does play a role with genetics. “A person can be born with the genetic mutation in all of their cells (germline mutation) or acquire a genetic mutation in a single cell during his or her lifetime. An acquired mutation is passed on to all cell that develop from that single cell(called somatic mutation).Somatic mutation can sometimes be caused by environmental factors, such as cigarette smoke” (Cancer.net, 2011).…

    • 1503 Words
    • 7 Pages
    Better Essays
  • Powerful Essays

    Cancer is a genetic disease, caused by changes to genes that control the way our cells function, especially how they grow and divide.…

    • 2130 Words
    • 9 Pages
    Powerful Essays
  • Powerful Essays

    BRCA1 is tumor repressor gene and plays an important role in breast cancer development. In the DNA double-stranded break (DSB) repair, loss of BRCA1 contributes to defective homologous recombination (HR) and predominant non-homologous end-joining (NHEJ), which leads to significant defects in genomic stability with increased amount of radial chromosomes that normally inhibits proliferation (Bunting et al., 2010). For the mice homozygous for null BRCA1 mutations, for example with exon-11 deletion (Δ11) isoform of BRCA1 (BRCA111/11), the organisms develop embryonic lethality, which display severe apoptosis (Liu et al., 1996; Ludwig et al., 1997). As a result, cells must acquire secondary mutations to allow proliferation and tumorigenesis in order to survive with BRCA1 deficiency (Aly and Ganesan, 2011). Almost all BRCA1-deficient cancer cells have acquired p53 mutations, but p53 function is not enough to overcome the growth defect resulted by BRCA1 loss. Losses of p53 can only delays embryonic lethality in full null BRCA1-mutant mice by a few days. Except this aspect, there are still several defects (Aly and Ganesan, 2011). These secondary mutations might interfere with the chemotherapeutic drug, the poly(ADP-ribose) polymerase (PARP) inhibitor, which lead to a great impact in cancer chemotherapy…

    • 2228 Words
    • 9 Pages
    Powerful Essays
  • Good Essays

    Brain Tumor Virology

    • 1388 Words
    • 6 Pages

    The field of tumor virology has provided groundbreaking insights into the causes of human cancer. Peyton Rous founded this scientific field in 1911 by discovering an avian virus that induced tumors in chickens. In the 1950s, Ludwik Gross sparked the first intense…

    • 1388 Words
    • 6 Pages
    Good Essays
  • Good Essays

    Epigenetic modifications in addition to genetic defects play a role in mechansims governing the occurence of cancer.…

    • 153 Words
    • 1 Page
    Good Essays
  • Good Essays

    Deoxyrionucleic acid, or DNA for short, is just one example of many technological breakthroughs that humans have made. Seventy years ago, no one knew what DNA was, didn’t even know that it existed. However, today that is different. It is now commonly known that DNA makes up all living things. This just proves that, while we may not have the cure for cancer today, we will find it tomorrow. It is apart of human nature to strive for greatness and inovation. This inovation will somday come in the form of a cure for cancer. Technology can and will enable the human race to find the cure for cancer. Once this remedy is found many lives will be touched and, in turn, many more after that.…

    • 400 Words
    • 2 Pages
    Good Essays
  • Good Essays

    I would like to take this opportunity to extend my sincere thanks to all the people who generously supported me during my PhD study. I would like to first express my deepest thanks to my supervisor Dr. David Adams. Since the first time I met him in the Sanger institute, he has been given me so much help and support all through the years. While I was working with the mice from the beginning, he opened up my mind to explore other areas based on my interest and under his guidance most efforts afterwards…

    • 51017 Words
    • 205 Pages
    Good Essays
  • Powerful Essays

    P53 Structure and Function

    • 15729 Words
    • 63 Pages

    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China [L. Bai, W.-G. Zhu]; Department of Biotechnology, Guilin Medical College, Guilin, China [L. Bai] Since the p53 tumor suppressor gene has been found to be mutated in more than 50% of human cancers, it has attracted the interest of numerous researchers. The capacity of p53 for multiple biological functions can be attributed to its ability to act as a sequence-specific transcription factor to regulate expression of over one hundred different targets, and thus to modulate various cellular processes including apoptosis, cell cycle arrest and DNA repair. The p53 protein with its unique C- and N-terminal structures is rigidly modulated by several important biological processes such as phosphorylation, acetylation and ubiquitination, through which it effectively regulates cell growth and cell death. p53 mutations can lead either to loss or change of p53 binding activity to its downstream targets and may thus induce aberrant cell proliferation, with consequent malignant cellular transformation. Based on p53’s critical role in carcinogenesis, scientists have developed multiple effective strategies for treating cancer by enhancing function of wild-type p53 or increasing p53 stability. This review will focus on (i) discussing of the relationship between p53 structure and function, (ii) p53 mutations, and (iii) recent strategies for improving the efficacy of cancer treatment by therapeutic manipulation of p53.…

    • 15729 Words
    • 63 Pages
    Powerful Essays