Biochem 305
Assignment #1
Biochem 305
1) name | 2) name of the coenzyme | 3) RDA mg/day | 4) comm-ercial amt/2capsules | 5)deficiency disease | symptoms of deficiency | 6) problem w/ high amt | B1 Thiamin | Thiamine pyrophosphate (TPP) | 1.1 | 17 mg | Beriberi | impairment of the nerves and heart muscle wasting | anaphylaxis to parenteral thiamin as well as pruritus due to allergic sensitivity to thiamin injection. | B2 Riboflavin | Flavin coenzymes | 1.1 | 17 mg | rare or unobserved | inflammation of the skin, tongue, and lips; ocular disturbances; nervous symptoms | | B3 Niacin | niacinamide,nicotinamide diphosphate (NAD), and nicotinamide diphosphate hydrate (NADH) | 14 | 50 mg | Pellagra | skin lesions, gastrointestinal disturbances, nervous symptoms | gastrointestinal effects for patients treated with nicotinic acid. Hepatic toxicity has been reported in patients treated medically with the vitamin. | B5 Pantothenic Acid | Coenzyme A | 1.3 | 50 mg | rare or unobserved | weakness, gastrointestinal disturbances, nervous symptoms, fatigue, sleep disturbances, restlessness, nausea | | B6 Pyridoxine | pyridoxal 5’-phosphate. | 1.3 | 17 mg | rare or unobserved | dermatitis, mental depression, confusion, convulsions, anemia | The critical adverse effect from high intake is neuropathy | B7 Biotin | Biocytin | 30 mcg | 200 mcg | rare or unobserved | dermatitis, hair loss, conjunctivitis, neurological symptoms | | B9 Folic Acid/Folat | folinic acid (5-formyl tetrahydrofolate) | 400 mcg/day | 533 mcg | Megaloblastic anemia | impaired formation of red blood cells, weakness, irritability, headache, palpitations, inflammation of mouth, neural tube defects in fetus | Excess folate may precipitate or exacerbate neuropathy in vitamin B12-deficient individuals. | B12 Cobalamin | methylcobalamin and adenosylcobalamin | 2.4 mcg/day | 533 mcg | Pernicious anemia | smoothness of the tongue, gastrointestinal disturbances, nervous symptoms | | Lipoate | Lipoic acid |
Biochem 305
1) name | 2) name of the coenzyme | 3) RDA mg/day | 4) comm-ercial amt/2capsules | 5)deficiency disease | symptoms of deficiency | 6) problem w/ high amt | B1 Thiamin | Thiamine pyrophosphate (TPP) | 1.1 | 17 mg | Beriberi | impairment of the nerves and heart muscle wasting | anaphylaxis to parenteral thiamin as well as pruritus due to allergic sensitivity to thiamin injection. | B2 Riboflavin | Flavin coenzymes | 1.1 | 17 mg | rare or unobserved | inflammation of the skin, tongue, and lips; ocular disturbances; nervous symptoms | | B3 Niacin | niacinamide,nicotinamide diphosphate (NAD), and nicotinamide diphosphate hydrate (NADH) | 14 | 50 mg | Pellagra | skin lesions, gastrointestinal disturbances, nervous symptoms | gastrointestinal effects for patients treated with nicotinic acid. Hepatic toxicity has been reported in patients treated medically with the vitamin. | B5 Pantothenic Acid | Coenzyme A | 1.3 | 50 mg | rare or unobserved | weakness, gastrointestinal disturbances, nervous symptoms, fatigue, sleep disturbances, restlessness, nausea | | B6 Pyridoxine | pyridoxal 5’-phosphate. | 1.3 | 17 mg | rare or unobserved | dermatitis, mental depression, confusion, convulsions, anemia | The critical adverse effect from high intake is neuropathy | B7 Biotin | Biocytin | 30 mcg | 200 mcg | rare or unobserved | dermatitis, hair loss, conjunctivitis, neurological symptoms | | B9 Folic Acid/Folat | folinic acid (5-formyl tetrahydrofolate) | 400 mcg/day | 533 mcg | Megaloblastic anemia | impaired formation of red blood cells, weakness, irritability, headache, palpitations, inflammation of mouth, neural tube defects in fetus | Excess folate may precipitate or exacerbate neuropathy in vitamin B12-deficient individuals. | B12 Cobalamin | methylcobalamin and adenosylcobalamin | 2.4 mcg/day | 533 mcg | Pernicious anemia | smoothness of the tongue, gastrointestinal disturbances, nervous symptoms | | Lipoate | Lipoic acid |