Resveratrol SIRT2: A Case Study

Resveratrol has been found to have many effects that are consistent with SIRT1 activation – for example, it improves insulin sensitivity, inhibits tumor growth, suppresses inflammation, promotes cardiovascular health, and protects against neurodegenerative diseases (Jang, Cai et al. 1997, Baur, Pearson et al. 2006, Baur and Sinclair 2006, Richard, Pawlus et al. 2011). Above all, resveratrol mimics transcriptional profiles associated with caloric restriction (Barger, Kayo et al. 2008, Pearson, Baur et al. 2008) and prevents early mortality in obese mice (Baur, Pearson et al. 2006).