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Linoleoyl Glycerol: PAF-AH Inhibitors

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Linoleoyl Glycerol: PAF-AH Inhibitors
C3170

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IC50: 45 µM

1-Linoleoyl glycerol is a PAF-AH inhibitor.

Platelet-activating factor (PAF), a biologically active phospholipid synthesized by a variety of stimulated cells, acts as a mediator of platelet aggregation, allergy, and inflammation. PAF is transformed to its biologically inactive lyso-PAF by the enzyme of PAF acetylhydrolase (PAF-AH). Furthermore, plasma PAF-AH has been related with atherosclerosis and may be a positive risk factor for coronary heart disease.

In vitro: 1-Linoleoyl glycerol had moderate Lp-PLA2 inhibitory activity, whereas its analog showed a very weak inhibitory activity. Their enantiomers were assessed for structural specificity against Lp-PLA2, leading to a very similar degree of inhibitory
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