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Free Radical Theory Of Aging Summary

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Free Radical Theory Of Aging Summary
After years of research studying the Free Radical Theory of Aging, Harman revised this theory to incorporate the role of mitochondria in aging. This “mitochondrial theory of aging” (Lee and Wei 2012, Bereiter-Hahn 2014) encompasses the effects of cumulative oxidative damage to mitochondria induced by ROS toxicity in the organism’s lifetime. The reactive oxygen species produced from metabolic respiration are associated with detrimental effects on mitochondrial function. Mitochondrial dysfunction then leads to abnormal amounts of ROS production, which further propagates oxidative
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