The diseases that are characterized by an abnormal accumulation of α-synuclein (-Syn) aggregates within neurons‚ nerve fibers‚ or glial cells are collectively referred to as α-synucleinopathies [1]. The three main types of α-synucleinopathies are Parkinson’s disease (PD)‚ dementia with Lewy bodies‚ and multiple system atrophy. These disorders impact mainly the elderly population‚ therefore causing serious personal and economic burden in our aging societies. Among them the most common disease is PD
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Gene therapy is being currently developed in labs across the world‚ with the goal of eventually being able to alter a person’s genetic make up effectively and consistently. If the subject has a missing or defective gene‚ scientists are able to inactivate the mutated gene and transplant a normal healthy one. Should the mutated gene be responsible for the lack of production to a particular protein‚ gene therapy may be able to restore normal function of the polypeptide and essential save the cell and
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cell necrosis Third stage: fibrotic tissue replace normal tissue. Therefore‚ Cirrhosis disease decrease production of the bile‚ as well production of blood- clotting factors. Hepatitis is the inflammation of the liver‚ caused by chemical or drug toxicity. There is several types of hepatitis. Hepatitis A virus‚ transmitted by fecal-oral route Hepatitis B virus‚ transmitted by infected blood‚ sexual transmission as well. Hepatitis C virus‚ transmitted by
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safe to handle with respect to the other chemicals used in the lab. This is why gloves were not worn‚ and one reason why this experiment follows GCP # 3 where chemical products should be designed to preserve efficacy of the function while reducing toxicity. 2. i. What was not green about this experiment is that solvents were used in this experiment. This does not abide by GCP # 5 in that solvents should be not used. However since the amount of HCL needs to be stopped to be titrated‚ the use of acetone
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conditions of inflammation such as narcotics (opioids)‚ and non narcotics (salicylates)‚ however these drugs accumulate side effects. That is why drugs from natural sources are referred to be a better inflammatory agent considering the presence of low toxicity and its therapeutic value. Natural drugs are considered as a big
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Complexometric Titration Topics to be discussed: • Complex ions & ligands. • EDTA in complexometric titration. • Indicators for complexometric titration. • Titration curve • Application of complexometric titration. 1 Complexometric titration method • An analytical method involving complex formation reactions. • A complex ion (or coordinate complex) is formed from electron donating compound & a metal ion. 2 Coordination Complex • The electron donating compound is a neutral organic molecule
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and is irreparable and can quickly lead to death. (Elpel‚ T (2011). The two vital organs that are affected first are usually the liver and the kidneys. This can quickly become a life threatening process. Although there is no cure for the toxicity‚ it has been treated with large doses of penicillin and Vitamin C‚ but there this is not a proven treatment and the only prevention of the ingestion of these mushrooms is safe. In most cases‚ if the person actually survives‚ a liver transplant
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Q1)- Green about this experiment: According to GCP#3 i.e. Less hazardous chemical synthesis: extraction of crude caffeine pose little toxicity to human health and the environment.(1) Q2) Things not green: According to GCP# 5 i.e. Safer solvent and auxiliaries: In liquid-liquid extraction of caffeine‚ Dicholoromethane was used which is a hazardous chemical and have potential acute health effects(2). According to GCP#12 i.e. Inherent safer chemistry for accident prevention: The separatory
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Urinary tract infection (UTI) is a bacterial infection or inflammation of the bladder (cystitis)‚ kidneys (pyelonephritis)‚ or urethra (urethritis)‚ leading to bacterial colonization of the urine. Infection of the urinary tract is a common problem‚ causing more than eight million office visits annually in the United States. UTI is the second most common infection that affects women. UTIs typically affect young‚ sexually active women. A lower UTI is an infection or inflammation of the bladder or urethra
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[pic] MANAGING RISKS OF HAZARDOUS CHEMICALS Draft Code of Practice Table of Contents FOREWORD 3 SCOPE AND APPLICATION 3 1. INTRODUCTION 5 1.1 Who has health and safety duties in relation to hazardous chemicals? 5 1.2 The meaning of key terms 6 1.3 What is required to manage the risks of hazardous chemicals? 7 2. HOW TO IDENTIFY HAZARDS 10 2.1 Labels and Safety Data Sheets (SDS) 10 2.2 Unlabelled containers 10 2.3 Hazardous chemicals generated
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