What is it? Sickle cell anemia is a type of blood disorder that can be inherited from parents. This is when red blood cells that are meant to carry oxygen around the body become deformed. Normal red blood cells are round and disc shaped‚ however‚ when they become sickle red blood cells‚ the deform and change shape into a crescent-like shape or sickle shape. The sickle cells have a shorter life-span than a healthy red blood cell and are not replaced as quickly as normal; this leads to a shortage
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SICKLE CELL ANEMIA Tina Thompson‚ Ashley Scott‚ Araceli Galindo‚ Roshanda Dixon‚ Kristen Wyatt‚ Kimberly Dennis What is Sickle Cell Anemia? Sickle cell anemia is a severe hemolytic anemia resulting in a sickle shaped hemoglobin molecule. It is an inherited disorder with some having sickle cell trait and some having sickle cell disease. The sickle hemoglobin gene is known as the HbS gene. It is found predominantly in people of African descent and occasionally in those of Mediterranean descent
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Observations: When Malaria is present and infects red blood cells‚ parasites can infect cells carrying defective hemoglobin which may result in death. Allele frequency changes over time depending on the pressures or circumstances facing a particular population. African populations are especially impacted by both malaria and sickle cell anemia. Depending on the impacted population‚ allele frequency often shifts and well suited organisms are likely to survive and allele frequencies can increase
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the complexities of Sickle cell anaemia and Sickle cell disease a basic understanding of haemoglobin is essential. (See appendix 2) Appendix 3 shows a normal red blood cell and a sickled red blood cell‚ you can see the difference is more than noticeable. This essay will look at three themes and look at areas of research found by the author‚ an analysis and evaluation of the research found will be given. A conclusion will then be given of the information found during the research process. The themes
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Genetics- Word Count: 214 Sickle cell disease is a genetic blood disorder that plagues millions of people all over the world‚ the highest concentration is found among people of Sub-Saharan African descent. Sickle cell disease is caused by a mutation in the HBB gene located on chromosome 11. Hemoglobin in red blood cells is how oxygen is delivered to cells throughout the body and is composed of four subunits‚ two subunits of alpha- globin and two of beta- globin. The HBB gene provides the instructions
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TREATMENT OPTIONS There is NO cure for sickle cell disease‚ although new stem cell research is promising. Bone marrow transplant is a potential cure‚ however finding a matched sibling donor is difficult. Therefore treatment is primarily focused on management of symptoms and prevention of pain episodes. Hydroxyurea (a chemotherapeutic medication) is the only recognized treatment option for the prevention of vaso-occlusive crisis in SCD. It is a prescribed drug for adult patients
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‘How could natural selection increase the number of children born with sickle-cell disease in certain regions when these individuals are unlikely to survive and produce offspring?’ Darwin’s theory proposes that 3 conditions are a requisite for natural selection to occur. They are a struggle for existence of the offspring as they are competing for limited resources‚ variation within species which gives some individuals advantage over others hence better chance of survival and lastly inheritance
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Sickle cell disease and the hope of stem cell therapies; ethics in the treatment sickle cell. The past half century has been an era of rapid discoveries: from the humble beginnings of molecular biology‚ discovery of the structure of DNA‚ research on recombinant DNA‚ the discovery of the human embryonic stem cell (ESC)‚ the completion of the Human Genome Projects‚ mammalian cloning and the discovery of ntESCs (nuclear transfer ESCs) by somatic cell nuclear transfer and the ethical sigh of relief
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Introduction: Sickle-cell anaemia (SCA) also called Sickle-cell disease (SCD)‚ is a genetic blood disorder. It occurs due to a mutation in the haemoglobin gene. In sickle-cell anaemia‚ red blood cells become rigid‚ less flexible and adopt sickle shape. Sickle-cell disease occurs more commonly among people whose ancestors lived in tropical and sub-tropical sub-saharan regions. In Sickle cell disease‚ human blood contains both normal red blood cells and sickle-shaped cells. Sickle-cell disease causes
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offspring. He also discovered that traits pass down through families in different patterns. Sickle cell‚ which is an inherited disease‚ is mainly found in those of African descent. Mendel’s research ultimately helped lead to the discovery and understanding of the HBS allele‚ the connection of malaria to sickle cell now and in future generations‚ and the new technology that helps diagnose and treat sickle cell. In 1910‚ a black man named Walter Clement Noel‚ went to Dr. James B. Herrick‚ complaining
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