How Acetylsalicylic Acid was Discovered Acetylsalicylic Acid in its earliest form was a powder for the bark and leaves of the willow tree. Hippocrates‚ who lived sometime between 460 B.C. and 377 B.C‚ founded it. This “Miracle Drug” that was able to relieve pains was later looked into with further detail by Johann Buchner. He isolated a tiny amount of bitter tasting yellow‚ need- like crystals‚ and called salicin. By 1829 French Chemist Henri Leroux had improved the extraction procedure to
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Experiment # 3 Acetylsalicylic Acid Introduction: The purpose of this experiment is to create and isolate pure acetylsalicylic acid from the substances salicylic acid and acetic anhydride. Then one will find the melting point to determine purity. Procedure: Make a hot bath. Weigh some salicylic acid and place in conical vial. Add .480mL of acetic anhydride and a drop of concentrated phosphoric acid. Drop in a magnetic spin vane and attach air condenser to vial. Partially submerge it in
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Acetylsalicylic Acid (Aspirin) Synthesis Telow‚ AJV Sumicad‚ CJ‚ Tavanlar‚ EMMT‚ Chem 40.1‚ Institute of Chemistry‚ University of the Philippines Los Baños I. Introduction Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials. The objective of organic synthesis is to design the simplest synthetic routes to a molecule. Aspirin‚ also known as acetylsalicylic acid is as salicylate drug often used as analgesic
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October 9‚ 2013 Partner(s): Acetylsalicylic Acid Synthesis Theory. This experiment was carried out to see how the hydroxyl group on the benzene ring in salicylic acid reacts with acetic anhydride to form an ester‚ and to make aspirin. Synthesis of Acetylsalicylic Acid occurs by protonation of carbonyl (C=O) group‚ and a nucleophilic attack of OH on the acetic anhydride. The ferric chloride test and melting point were used to test the purity of the results. A hypothesized recovery rater of above
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Aspirin analysis Introduction Aspirin‚ which is also known as acetylsalicylic acid. C9H8O4 is the chemical format for Asprin. The chemical structure of aspirin: Aspirin is anti-inflammatory. Aspirin is prepared by chemical synthesis from salicylic acid‚ by acetylation with acetic anhydride. The fact that it is an acid allows us to quantify the amount of aspirin in a solution. We would do this by by using an acid-base titration. Sodium hydroxide (NaOH) will be used In this experiment as the
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What is acetylsalicylic acid? Acetylsalicylic acid (ASA)‚ or more commonly known as aspirin‚ is a medication that can be used for pain‚ fevers‚ and inflammation. It can be used for long periods of time‚ in small amounts‚ to prevent heart attacks‚ strokes and the formation of blood clots. A heart attack victim can be given a low dose right after the ordeal to reduce the risk of another one. Side effects of this drug is ulcers‚ internal bleeding (stomach) and ringing in the ears. These mainly happen
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Preparation of Acetylsalicylic Acid Abstract Acetylsalicylic acid was prepared using salicylic acid and acetic anhydride. As a result‚ a white‚ powdery substance was formed (0.1931g‚ percent yield 91.30%) and was defined by melting point (124.5 – 134.5°C) and observation of color change with ferric chloride. Introduction Acetylsalicylic acid (aspirin) is one of the most popular analgesic drugs on the market today. It also acts as an antipyretic and anti-inflammatory drug. Salicylic acid itself was
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EXERCISE 11 Synthesis of Aspirin (Acetylsalicylic Acid from Salicylic Acid) RAQUID‚ Rency J Group 5 18L I. Introduction Due to the demand of certain reagents in the laboratory in order to perform and conduct further experiments or produce essential compounds‚ chemists continuously develop organic synthesis. This process aims to prepare and synthesize desired organic compounds from commercially or readily available ones by providing the simplest route in synthesizing the compound
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Tecson Gamido‚ Mitchiko Mariel M. Mizukami Abstract Acetylsalicylic acid‚ or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride‚ both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In order to create the powder form of
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purification of acetylsalicylic acid Results and Data treatment (A) Preparation of aspirin i) Details about the reactants Reaction of the acetylation of salicylic acid is following From the balanced reaction above‚ it can be seen that the stoichiometry between salicylic acid and acetic anhydride is 1: 1. In this experiment‚ 21.7mmol of salicylic acid was used to react 6.0mL of acetic anhydride and salicylic acid was limiting reagent. The expected amount of salicylic acid used: 21.7/1000*138
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