Journal of Health Economics 22 (2003) 151–185 The price of innovation: new estimates of drug development costs Joseph A. DiMasi a‚∗‚ Ronald W. Hansen b‚ Henry G. Grabowski c a Tufts Center for the Study of Drug Development‚ Tufts University‚ 192 South Street‚ Suite 550‚ Boston‚ MA 02111‚ USA b William E. Simon Graduate School of Business Administration‚ University of Rochester‚ Rochester‚ NY‚ USA c Department of Economics‚ Duke University‚ Durham‚ NC‚ USA Received 17 January 2002; received
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Midland Energy Resources Midland Energy Resources is a fully integrated energy company with operations in E&P‚ Refining & Marketing (R&M) and Petrochemicals. Capital budgeting at Midland is done using discounted cash flow method and weighted average cost of capital (rwacc). Corporate Weighted Average Cost of Capital‚ rwacc The primary use of the corporate rwacc is valuation (TV=FCF/(rwacc-g)). While the rwacc may be used for evaluating internal projects‚ the usage will be incorrect owing to the
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Napalm has been used in World War 2‚ but became famous in the Vietnam War. It was first used as a weapon against buildings‚ but later it became a weapon against other soldiers. Napalm was very effective against people‚ because it sticks to the skin and causes extreme burn wounds. Napalm is quite an inhumane weapon. When napalm was created in World War 2‚ it was used in flamethrowers. Later in World War 2‚ Napalm was put into bombs‚ which were dropped on targets. The U.S. Army used Napalm‚ because
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traders can set up their business with just hundreds of pounds‚ where as a PLC has to have £50‚000 at least by law to set up one. Privacy – No information about the business has to be made public‚ and the only people that need to see information on how the business has been run and the profits it has made are the Inland Revenue and HM Customs and Excise. Flexibility – Although there are a lot of hours needed to be put in to run a sole proprietorship‚ sole traders get to choose when they work.
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JOCELYN T. BALAGUSA BSED-Supplemental How Values Affect A Person Values are set of beliefs to which a person refers to in times of crisis. That is when the person is confronted with the hardest decision to make. Say for instance‚ while I was taking a walk along the downtown area of Tacloban City‚ I saw an old woman carrying a pocket full of cash. Maybe she just came from selling her copra from a nearby buying shop. From her disheveled look‚ she was a real rural folk. I was so amused with
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How and why is a social group represented in a particular way? How are the witches portrayed and what influence do they have along the play? In Macbeth‚ the witches seem to be confusing figures. They are portrayed as dark‚ eccentric‚ and strangely amusing creatures. It doesn’t show that they have that much importance early on‚ but after finishing the play and comprehending‚ we see that the witches have done a lot. We can deduce that the “weird sisters” specifically implant ideas in Macbeth’s
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California has been the largest producer of garlic in the United States since it was introduced in the early 1700s. Garlic is thought to be originated in central Asia‚ functioning as a medical alleviation. Although it is still used in medicine‚ its main purpose nowadays is in flavoring food. As garlic is shifting to a principal ingredient in many American restaurants‚ production is rapidly increasing however‚ acreage is dropping. In fact‚ in 1999 there were about 40‚000 acres in the valley whereas
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BlackDoctor.org) -- Federal health researchers said this week that a whopping half of African American teenage girls have a sexually transmitted infection. That fact is troubling enough‚ but it’s all the more so when you consider its implications for the Black AIDS epidemic. The Centers for Disease Control and Prevention released the study‚ which is the first of its kind‚ on March 11 at its annual STD prevention conference. Researchers culled through 2003-2004 data in an ongoing‚ annual health survey
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E3’s GH16 Written Knowledge 1) Our salon’s requirements for client preparation are to ensure clients are gowned and all their clothes are protected. Then to ensure there is a cutting collar placed around the client’s neck before the stylist starts to cut. 2) Our salons expected service time for a cut and style is 1 hour. 3) The salons legal requirements for disposal of sharps are to place all sharps in the sharp bin. All waste materials must be securely bagged and placed in the outside bin
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The Roaring Twenties is traditionally viewed as an era of great economic prosperity driven by the introduction of a wide array of new consumer goods. The North American economy‚ particularly the economy of the US‚ transitioned from a wartime economy to a peacetime economy; the economy subsequently boomed. The United States augmented its standing as the richest country in the world‚ its industry aligned to mass production and its society acculturated into consumerism. In Europe‚ the economy did not
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