Sickle-Cell Disease Discovery: http://www.sicklecellanaemia.org/sickle-cell-disease/discovery-of-sickle-cell-disease James Herrick was a doctor in Chicago‚ USA‚ and wrote about his observations of a patient with severe anaemia. When blood samples were viewed under the microscope Herrick noted “peculiar elongated and sickle-shaped red blood corpuscles”. Symptoms: http://www.nhlbi.nih.gov/health/health-topics/topics/sca/ Sickle cell anemia varies from person to person. Some people who have
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Anemia? Sickle cell anemia is a severe hemolytic anemia resulting in a sickle shaped hemoglobin molecule. It is an inherited disorder with some having sickle cell trait and some having sickle cell disease. The sickle hemoglobin gene is known as the HbS gene. It is found predominantly in people of African descent and occasionally in those of Mediterranean descent. Pathophysiology The defective hemoglobin molecule assumes a sickle shape when it is exposed to low oxygen tension. These long‚ rigid
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quantitative deficiency of the hemoglobin‚ often accompanied by a reduced number of red blood cells and causing pallor‚ weakness‚ and breathlessness. Prognosis-a forecasting of the probable course and outcome of a disease‚ especially of the chances of recovery Trait-This passed on in sex chromosones Symptom a phenomenon that arises from and accompanies aparticular disease or disorder and serves as an indication of it. Beta-globin the chain of hemoglobin that is designated beta and that
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bone marrow ‚a gene in the bone marrow causes the blood cell to come out in a sickle cell shape because the hemoglobin in the defected body is abnormal‚ after it gives up the oxygen‚ bet together causeing the red blood cells to become to a sickle like shape.People with Sickle cell anemia have abnormal hemoglobin in their red blood cells.which cause the blood cell to die quicker Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. This disease is passed by genes from
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anemia. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re stiff and sticky and tend to form clumps and get stuck in the blood vessels. The sickle cells also get stuck in blood vessels‚ blocking blood flow. This can cause pain and organ damage. Sickle cell disease is caused by a mutation in the beta-globin chain of the hemoglobin molecule. Sickle hemoglobin‚ the result of this mutation‚ has the
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gene. Researchers are exploring whether inserting a normal gene into the bone marrow of people with sickle cell anemia will result in the production of normal hemoglobin. Scientists are also currently exploring the possibility of turning off the defective gene while reactivating another gene responsible for the production of fetal hemoglobin which is found in newborns. Trials using genes specifically for sickle cell have yet been done. (Mayo Clinic‚ 2016) In conclusion understanding the basics of
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FLORIDA INTERNATIONAL UNIVERSITY COLLEGE OF HEALTH AND URBAN AFFAIRS SCHOOL OF NURSING CLINICAL WORKSHEET: NURSING PROCESS CARE PLAN STUDENT NAME DATE |Client Initials A.R |Culture/Ethnicity White |Support system Mother‚ Father | |Unit Telemetry Room/Bed 478D |Religion Catholic |
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Analysis of Glycated Hemoglobin by HPLC Technology Shalini Kini Product Specialist Diabetic EpidemiologyWhere Do we Stand!?! World Scenario * IDF Diabetes Atlas 5th Edition 2012 update. http://www.idf.org/diabetesatlas/5e/Update2012 Did U Know!!??! One Adult in Ten will have diabetes by 2030!!! Year 2012 Year 2030 63.01m India 101.2m India • India Ranked Second in the world in Diabetes Prevalence‚ behind China. *IDF Diabetes Atlas- Fifth Edition http://www.idf
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Paul Manggahas‚ Luis Manio‚ Love Joy Masigan‚ Stephanie Kyra Mendiola‚ Roxanne Mendoza‚ Jullienda August 2014 I. Structure Myoglobin is almost similar in structures with hemoglobin except on the heme groups attached to it and to the presence of amino acids. Myoglobin only seems like a quarter of hemoglobin. Myoglobin has a molecular weight of 18‚ 000. It has a component of a single polypeptide chain folded into 8 α- helical structure‚ 153 amino acids and one heme group attached at the
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(CO2)|18||17-31|| Chloride (Of)|110||98-108|| Cholesterol||||| Creatine Phosphokinase (CPK or CK-MB)||||| Creatinine|0.30||0.1-0.7|| Ethyl Alcohol content (ETON)||||| Glucose|81||55-110|| Glutamyl Transpeptidase Test (GOT)||||| Glycosylated Hemoglobin (Hb A1c)||||| High-density Lipoprotein (HDL)||||| nomocysteine||||| Hormone Test||||| Iron (Fe)||||| Lactate Dehydrogenase (LDH)||||| Lipase||||| (*) Tests|Patient Results&Date|Patient Results &Date|Normal|Possible causes for out of
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