synthesize and purify aspirin. The theoretical yield was calculated to 3.766g. The actual yield of pure aspirin was 2.863g with a yield of 76%. The percent yield indicates that our synthesis was a success but the yield is low and indicates that some of the aspirin was lost during synthesis. Some reasons for loss can result from human error such as loosing product from sticking on the spatula and the Buchner funnel and several weighings. Also‚ when transferring the crude aspirin into the vacuum filtration
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EXERCISE 11 SYNTHESIS OF ASPIRIN MARAVILLA‚ Ana Mikaela B Group 4 CHEM 40.1 1L Date performed: September 30‚ 2013 Date submitted: October 7‚ 2013 VI. RESULTS AND DISCUSSION Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized
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Synthesis of Aspirin and Oil of Wintergreen INTRODUCTION: Synthesis and use of organic compounds is an extremely important area of modern chemistry. Approximately half of all chemists work with organic chemicals. In everyday life‚ many if not most of the chemicals you come in contact with are organic chemicals. Examples include drugs‚ synthetic fabrics‚ paints‚ plastics‚ etc. Synthesis of Aspirin and Methyl Salicylate. The two compounds we will be preparing‚ aspirin (acetylsalicylic acid) and oil
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Preparation of an Ester Acetylsalicylic Acid (Aspirin) OBJECTIVE: To become familiar with the techniques and principle of esterification. DISCUSSION: Aspirin is a drug widely used as an antipyretic agent (to reduce fever)‚ as an analgesic agent (to reduce pain)‚ and/or as an anti-inflammatory agent (to reduce redness‚ heat or swelling in tissues). Chemically‚ aspirin is an ester. Esters are the products of reaction of acids with alcohols‚ as shown in the following equation using
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Synthesis of Aspirin Name: Xuanyi Li Teaching assistant: Deirdre Zwilling November 15‚ 2009 Purpose: To synthesize aspirin‚ a common analgesic drug‚ via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride. The whole reaction is catalyzed by phosphoric acid. (The experiment involved three parts: The synthesis of aspirin‚ the isolation and purification of aspirin‚ and the estimation of the purity of the final product.) [pic] Procedure[1]: A mixture
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Greaves Chem3301-112 June 19‚ 2013 Synthesis of Aspirin from Methyl Salicylate Introduction The synthesis of Aspirin (Acetyl Salicyclic Acid) began with methyl salicylate and sodium hydroxide as the reagent. The polar oxygen accepts the electrons from now positively charged hydrogen. The positively charged sodium disassociates leaving the hydroxide ion with a negative Scheme 1 shows the mechanisms that were demonstrated during the synthesis of Aspirin. charge that attracts to the positively charged
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History Of Aspirin Aspirin is one of the most commonly used drugs in the world.. For centuries people throughout the world. Aspirin was discovered about 3500 years ago. A collection of 877 medicinal recipes‚ The Ebers papyrus‚ before Christ‚ from the middle of the second millennium had been bought during the last century from an Egyptian street vendor by Georg Ebers‚ a German Egyptologist Georg. He recommended an infusion of dried myrtle leaves for rheumatic and back pain. More than a
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IB1 Chemistry Practical #8 ANALYSIS OF ASPIRIN TABLETS For a long time the bark of the willow tree (salix alba) was used as a traditional medicine to relieve the fever symptoms of malaria. In the 1860’s chemists showed that the active ingredient in willow bark is salicylic acid (2-hydroxybenzoic acid) and by 1870 salicylic acid was in wide use as a pain killer (analgesic) and fever depressant (antipyretic). However‚ because it is a relatively strong acid‚ salicylic acid has the undesirable side effect
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Executive Summary The report will analyze the case study discussing the bribery scandal at Siemens AG. The case study raised the question of accountability of senior managers to the rampant corruption occurring in global divisions. Siemens AG is a German based company with executive offices in Munich. Siemens builds locomotives‚ traffic control systems and infrastructure. The company was brought up on charges of violation to the FCPA as a result of bribes of government officials. Outlining
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Today‚ aspirin is one of the most widely used medication on this Earth and has been since its popular breakout in the late 1890s. Long before we were born there was no such thing of a medication called aspirin. Instead‚ ancient people used willow leaves and bark from trees to help relieve oneself from pain and fevers. Aspirin as we come to know it in the form of an acetylsalicylic acid‚ was introduced to the world by Chemist Felix Hoffmann who was working at Bayer pharmaceutical company located in
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