Cystic fibrosis is caused by a mutated gene‚ cystic fibrosis transmembrane conductance regulator. It’s a disease that changes the way your body makes mucus and sweat. It also changes how well your lungs‚ digestive system‚ and other body parts work. Cystic fibrosis causes your mucus to be too thick‚ or sweat to be too salty. Mucus that is too thick causes your lungs to clog and makes it hard to breathe. It can block your pancreas‚ so you can’t digest your food very well. I believe that cystic fibrosis
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CYSTIC FIBROSIS Lori Alley Erika Lemerande Nicole Carpenter Maureen Joseph June Reyes Clinical Description and Definition of the Disease. “Cystic Fibrosis is a life threatening‚ genetic disease that causes persistent lung infections‚ and progressively limits the ability to breathe” (“Cystic Fibrosis‚” n.d.). Pathophysiology and History of the Disease • Cystic Fibrosis is caused by defects in the cystic fibrosis gene. • Cystic Fibrosis was recognized over 400 years ago in Germany. • There is no
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CF is an autosomal recessive disorder caused by a mutation of the gene that encodes for a chloride channel called the cystic fibrosis transmembrane conductance regulator (CFTR). In ductal epithelial cells‚ CFTR is highly expressed and functions to transport fluid and anions into the lumen. Dysfunction of the CFTR gene leads to a decrease in luminal fluid volume and decreased pH‚ resulting in protein precipitation within the ductal lumen and loss of normal acinar cell function. Estimated gene frequency
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Cystic Fibrosis is caused by a fault in the cystic fibrosis transmembrane conductance regulator (CFTR) gene on chromosome 7 at q31.2. For CF to be expressed‚ a faulty copy of the gene must be present at both alleles; autosomal recessive. Therefore both parents must be carriers of‚ or affected by the cystic fibrosis gene (fig. 1) for the gene to be passed on. If a person has one copy of the faulty allele (are heterozygous) they are carriers of the gene and can pass this allele on; if they possess
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Material Genetics Worksheet Review the images below and answer the follow-up questions. Questions: 1. According to the pedigree‚ is cystic fibrosis inherited as a dominant or as a recessive trait? Explain how you made your conclusion using evidence from the pedigree and the principles of genetics. -Cystic fibrosis is inherited as a recessive trait. Each child of 2 carriers has a ¼ chance of inheriting 2 recessive alleles
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1. Describe the symptoms of cystic fibrosis. The different symptoms of cystic fibrosis include repeated infections and thick mucus secretions in the lungs‚ it affects you with wheezing‚ a chronic cough‚ bronchitis‚ asthma‚ weight loss‚ dehydration‚ and many more mainly affecting the lungs and stomach. Sufferers may also feel very fatigued easily. 2. Describe two problems associated with the presence of thick‚ sticky mucus (a) in the lungs and breathing passageways (b) in the digestive system
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Cystic Fibrosis Cystic Fibrosis is caused by a single faulty gene that controls the movement of salt in the body. In people with Cystic Fibrosis‚ the internal organs become clogged with thick‚ sticky mucus resulting in infections and inflammation making it hard to breathe and digest food. For a baby to be born with Cystic Fibrosis‚ both parents must be carriers of the faulty CF gene. The diagram shows how CF is inherited. Where both parents carry the faulty gene‚ each child has a one in four chance
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Question number 1 The disease cystic fibrosis causes the buildup of salts to occur outside the cells of the tissue that lines human lungs. The salt draws in water‚ creating sticky‚ thick mucus that causes chronic breathing difficulties and eventually death. Which cell organelle is most likely defective in this case‚ and why? Solution According the medical experiment‚ cystic fibrosis disrupts the normal functioning of epithelial cells whose working is to make sweet glands in various parts of body
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On researching new developments in the treatment of cystic fibrosis‚ I came across a very interesting article: “Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.” In the article‚ Viet et al1 reveal the potential application of the silencing of RPL12 (Ribosomal Protein L12)‚ to correct the ΔF508-CFTR biogenesis defect. As you know‚ cystic fibrosis is caused by a defect in the CF transmembrane conductance regulator (CFTR gene)‚ or more specifically‚ mutations
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Cystic fibrosis is an inherited disease of secretory glands‚ including the glands that make mucus and sweat. "Inherited" means that the disease is passed through the genes from parents to children1‚ 2. People who have cystic fibrosis inherit two faulty cystic fibrosis genes one from each parent. The parents likely don’t have the disease themselves. Cystic fibrosis mostly affects the lungs‚ pancreas‚ liver‚ intestines‚ sinuses‚ and sex organs. Mucus is a substance made by the lining of some body tissues
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