Los Angeles bank loan officer Carl Allen (Jim Carrey) has become withdrawn since his divorce from ex-wife Stephanie (Molly Sims). Routinely ignoring his friends Pete (Bradley Cooper) and Rooney (Danny Masterson), he has an increasingly negative outlook on his life. One day, an old colleague suggests that he goes to a "Yes!" seminar with him, which encourages its attendants to seize the opportunity to say "Yes!". Carl considers the option, but subsequently misses Pete's engagement party. An irate Pete turns up at his house and berates him, telling him that he will end up completely lonely if he does not change his life. Carl decides to attend the seminar and meets inspirational guru Terrence Bundley (Terence Stamp), who publicly browbeats him into making a covenant with himself. Carl reluctantly promises to stop being a "No Man" and vows to answer "Yes!" to every opportunity, request or invitation that presents itself thereafter.
After the seminar, saying yes to a homeless man's request only leaves Carl stranded in Elysian Park. Disillusioned, he hikes to a gas station where he meets Allison (Zooey Deschanel), an unorthodox young woman. She gives him a ride back to his car on her scooter and kisses him before leaving. After this positive experience, Carl feels more optimistic about saying yes. However, he refuses oral sex from his elderly neighbor Tillie (Fionnula Flanagan), which results in falling down the stairs and almost getting attacked by a dog. Seeing the repercussions of saying no, he goes back to Tillie. While initially disgusted with the thought, Carl is ultimately pleasured by Tillie and thoroughly enjoys his time spent with her.
Carl starts to seize every opportunity that comes his way. He renews his friendship with Pete and Rooney, builds up a bond with his boss, Norman (Rhys Darby), assists Pete's fiancée, Lucy (Sasha Alexander), attends Korean language classes, joins a Persian dating website, and much more. Saying yes constantly works to...
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