Why Would Phosphorylation Cause A Conformational Change In A Protein
1. What is phosphorylation?
Phosphorylation is the covalent addition of a phosphate group to a molecule. The addition usually occurs to a protein.
2. What three amino acids are that will be phosphorylated and why?
Amino acids that will be phosphorylated are serine, tyrosine, and threonine. All three of these amino acids contain a hydroxyl group. A hydroxyl groups is necessary for ATP hydrolysis.
3. Using what you know about protein structure and the charge on a phosphate molecule, why would phosphorylation cause a conformational change in a protein?
Let’s say, for example, a phosphate adds to a protein that is hydrophobic. According to Eric Bank (2017), the negative charge on the phosphate will make the macromolecule have an overall negative
Phosphorylation is the covalent addition of a phosphate group to a molecule. The addition usually occurs to a protein.
2. What three amino acids are that will be phosphorylated and why?
Amino acids that will be phosphorylated are serine, tyrosine, and threonine. All three of these amino acids contain a hydroxyl group. A hydroxyl groups is necessary for ATP hydrolysis.
3. Using what you know about protein structure and the charge on a phosphate molecule, why would phosphorylation cause a conformational change in a protein?
Let’s say, for example, a phosphate adds to a protein that is hydrophobic. According to Eric Bank (2017), the negative charge on the phosphate will make the macromolecule have an overall negative