By David Quammen Evolution by natural selection, the central concept of the life's work of Charles Darwin, is a theory. It's a theory about the origin of adaptation, complexity, and diversity among Earth's living creatures. If you are skeptical by nature, unfamiliar with the terminology of science, and unaware of the overwhelming evidence, you might even be tempted to say that it's "just" a theory. In the same sense, relativity as described by Albert Einstein is "just" a theory. The notion that Earth orbits around the sun rather than vice versa, offered by Copernicus in 1543, is a theory. Continental drift is a theory. The existence, structure, and dynamics of atoms? Atomic theory. Even electricity is a theoretical construct, …show more content…
The capacity for quick change among disease-causing microbes is what makes them so dangerous to large numbers of people and so difficult and expensive to treat. They leap from wildlife or domestic animals into humans, adapting to new circumstances as they go. Their inherent variability allows them to find new ways of evading and defeating human immune systems. By natural selection they acquire resistance to drugs that should kill them. They evolve. There's no better or more immediate evidence supporting the Darwinian theory than this process of forced transformation among our inimical germs. Take the common bacterium Staphylococcus aureus, which lurks in hospitals and causes serious infections, especially among surgery patients. Penicillin, becoming available in 1943, proved almost miraculously effective in fighting staphylococcus infections. Its deployment marked a new phase in the old war between humans and disease microbes, a phase in which humans invent new killer drugs and microbes find new ways to be unkillable. The supreme potency of penicillin didn't last long. The first resistant strains of Staphylococcus aureus were reported in 1947. A newer staph-killing drug, methicillin, came into use during the 1960s, but methicillin-resistant strains appeared soon, and by the 1980s those strains were widespread. Vancomycin became the next great weapon against staph, and the first vancomycin-resistant strain emerged in 2002. These antibioticresistant strains represent an evolutionary series, not much different in principle from the fossil series tracing horse evolution from Hyracotherium to Equus. They make evolution a very practical problem by adding expense, as well as misery and danger, to the challenge of coping with staph. The