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Tricyclic Antidepressants Research Paper

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Tricyclic Antidepressants Research Paper
TriCyclic Antidepressants (TCAs). This kind of antidepressants are one of the first drugs to be used for treating depression. TCAs work the same way as SNRIs. However, TCAs affect other chemical messengers, which cause many side effects. TCAs have been replaced in popularity due to the side effects they bring, which include urinary retention, constipation, weight loss, weight gain due to increased appetite, profuse sweating, tremors, delayed orgasms, lowered sex drive, tremors, blurred vision, dizziness and drop in blood pressure. Some doctors still prescribe TCAs when other kinds of medication have failed. The most used TCAs include amitriptyline, amoxapine, desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil) and trimipramine (Surmontil).
Noradrenaline-Serotonin Specific Antidepressants (NaSSAs). NaSSAs increase the concentration of the neurotransmitters serotonin and norepinephrine while blocking 5HT2 and 5HT3 receptors, an action that leads to the lessening of side effects like anxiety, headaches, vomiting, …show more content…
This class of antidepressants block the absorption of norepinephrine, a neurotransmitter that increases blood flow to the muscles and sharpens mental focus. Like any other medication, NARIs also have side effects, which include excessive sweating, difficulty sleeping, difficulty urinating, sexual difficulties and increased heart rate. These are some of NARIs used for depression and other mental and behavioural disorders: bupropion (Wellbutrin, Zyban), atomoxetine (Strattera), maprotiline (Ludiomil), viloxazine (Vivalan) and eboxetine (Edronax).
Monoamine Oxidase Inhibitors (MAOIs). This type of antidepressant is the first to be developed and used as a treatment for depression. Although effective in changing brain chemistry and lifting the fog of depression, they are not as popular as newer antidepressants because of the side effects that come with their
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