Tight Junction

Tight junctions (TJs) are occluding junctions which act as barriers that control paracellular permeability and regulate trans-epithelial water and solute movement. The structures are composed of integral transmembrane proteins that link adjacent cells, with an effect on cell-cell adhesion and epithelial permeability. It also works as a boundary between the apical and basolateral plasma membrane domains to create the polarisation of endothelial and epithelial cells. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extra cytoplasmic leaflet.

Figure 1: Tight junction location between the epithelial cells and paracellular transport.
(Singh, Sharma, and Dhawan, 2010)

Claudins

Claudin in ovarian cancer Claudin proteins consists of 24 transmembrane proteins exhibiting distinct tissue and are the main component of tight junctions that function as selective barriers. Claudins are expressed in both epithelial and endothelial cells in which they form a complex with occluding (Leech A.O et al 2015). Clauidns play important roles in forming and function of the tight junction in normal epithelial and endothelial cells.
Claudins form the backbone of TJs and interrelate with each other in
The ovaries are the female reproductive organs which produce eggs (ova) as well as female hormones oestrogen and progesterone. Ovarian cancer is the fourth leading cause of cancer among women in Europe and United States, there are more deaths than in any other cancer due to difficulties in diagnosis and therapy. In UK ovarian cancer is the fifth most common cancer in women, around 7000 cases were recorded in 2012. According to (Globocan 2012) approximately 239000 women were to have been diagnosed with ovarian cancer in 2012, and is the eighth most common cause of cancer death in women