Paige Collins (Rachel McAdams) and her husband Leo (Channing Tatum) come out of a movie theater. On their way home, at a stop sign, Paige unbuckles her seatbelt to lean over and kiss Leo. At that very moment, a truck rams their car from behind and Paige crashes through the windshield. Both of them are rushed to the emergency room, and as Leo, in a voice-over talks about how "moments of impact help in finding who we are" the movie cuts to how Paige and Leo first met. The scenes of how they courted, proposed and married are interwoven with the present.
When Paige regains her consciousness, she thinks Leo is her doctor, having lost all memories of the past few years. When her parents, Bill and Rita Thornton, learn about this and visit her, it is the first time that Leo meets them. Paige does not understand why she left law school, broke her engagement with her previous fiancé, Jeremy, and why she has not been in touch with her family and friends. Her parents insist on taking her home with them and Paige agrees, assuming she might have married Leo for some mutual benefit and seeks evidence for the marriage. Just as she's about to leave, Leo comes running to play her a voice message in which she sounds very happy and romantic. Paige decides to go back with Leo, hoping it will help her regain her lost memory. Paige is welcomed home with a surprise party by her friends, but as she is not able to remember any of them, she finds it overwhelming and bursts out in anger.
The next day Paige ventures out to her regular cafe but does not remember having been there and loses her way back. She calls her mother because she does not know or remember Leo's number. That evening Leo and Paige are invited for dinner by her parents. At the dinner and in the bar later, Leo does not fit in with her family and friends. He persists in his attempts to help her regain her memory, but Paige is more driven to learning why she left law school and broke her engagement to Jeremy. During the...
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