synthesis of asprin
Nitration of Acetanilide
Introduction
When organic compounds are nitrated it changes the composition and reaction of the compounds.[4] We could benefit from these changes, nitration of acetanilide produces a product called p- Nirtoanoline. P-Nitroaniline is commonly used as an intermediate in the synthesis of dyes, antioxidants, pharmaceuticals and gasoline. P-Nitroaniline is also used in gum inhibitors, poultry medicines and as a corrosion inhibitor. [2] Nitration is a type of chemical reaction which a nitro group is added to or substituted in a molecule. It can be carried out by a mixture of concentrated nitric acid and sulfuric acid. Mixture is useful to obtain the active nitronium ion. Electrophilic aromatic substitution is a method used when a functional group is needed to be substituted on to an aromatic compound. In the nitration, nitronium ion acts as the electrophile that involves the attack of the electron-rich Benzene ring. [3] In this experiment nitration is carried out using acetanilide and allows this chemical to be used in a way that could be beneficial for our use.
Procedure
Gathering products
Weighed out 0.202g of acetanilide powder and add 500µl of sulfuric acid to the viol, stir and loosen up clumps. Obtained another clean conical viol, added 110µl of nitric and sulfuric acid to the clean conical viol, then we put the viol with the acid mixture on ice.
Nitration
We added 55µl of the acid mixture (nitric and sulfuric acid) to the viol with the acetanilide and sulfuric acid. We did this for a total of three times until all the acid mixture was added to the acetanilide viol. We put the acetanilide mixture viol in a 10 mL beaker of ice water for 10 minutes. Added 2 mL of ice and water to the acetanilide viol.
Filtration
We filtered and dried the product using the Hirsch funnel filtration, while rinsing the viol with 1 mL of DI water to get the rest of the acetanilide mixture out of the viol. Allow the
Introduction
When organic compounds are nitrated it changes the composition and reaction of the compounds.[4] We could benefit from these changes, nitration of acetanilide produces a product called p- Nirtoanoline. P-Nitroaniline is commonly used as an intermediate in the synthesis of dyes, antioxidants, pharmaceuticals and gasoline. P-Nitroaniline is also used in gum inhibitors, poultry medicines and as a corrosion inhibitor. [2] Nitration is a type of chemical reaction which a nitro group is added to or substituted in a molecule. It can be carried out by a mixture of concentrated nitric acid and sulfuric acid. Mixture is useful to obtain the active nitronium ion. Electrophilic aromatic substitution is a method used when a functional group is needed to be substituted on to an aromatic compound. In the nitration, nitronium ion acts as the electrophile that involves the attack of the electron-rich Benzene ring. [3] In this experiment nitration is carried out using acetanilide and allows this chemical to be used in a way that could be beneficial for our use.
Procedure
Gathering products
Weighed out 0.202g of acetanilide powder and add 500µl of sulfuric acid to the viol, stir and loosen up clumps. Obtained another clean conical viol, added 110µl of nitric and sulfuric acid to the clean conical viol, then we put the viol with the acid mixture on ice.
Nitration
We added 55µl of the acid mixture (nitric and sulfuric acid) to the viol with the acetanilide and sulfuric acid. We did this for a total of three times until all the acid mixture was added to the acetanilide viol. We put the acetanilide mixture viol in a 10 mL beaker of ice water for 10 minutes. Added 2 mL of ice and water to the acetanilide viol.
Filtration
We filtered and dried the product using the Hirsch funnel filtration, while rinsing the viol with 1 mL of DI water to get the rest of the acetanilide mixture out of the viol. Allow the