Since mammals do not synthesize their own folic acid, PABA inhibitors such as sulfanilamide selectively kill bacteria without injuring the host (Figure 1). One of the most well-known preparation techniques of sulfanilamide is achieved by treating aniline with excess chlorosulfonic acid via replacement of hydrogen with a sulfonyl chloride group. This reagent forms sulfonic acid first before being converted into a sulfonyl chloride by the excess chlorosulfonic acid (Scheme 1). A key method of sulfanilamide production via this chlorosulfonic acid is the synthesis of p-acetaminobenzenesulfonyl chloride (P-ASC), in which a large quantity of sulfonic acid is required. This can pose serious environmental
Since mammals do not synthesize their own folic acid, PABA inhibitors such as sulfanilamide selectively kill bacteria without injuring the host (Figure 1). One of the most well-known preparation techniques of sulfanilamide is achieved by treating aniline with excess chlorosulfonic acid via replacement of hydrogen with a sulfonyl chloride group. This reagent forms sulfonic acid first before being converted into a sulfonyl chloride by the excess chlorosulfonic acid (Scheme 1). A key method of sulfanilamide production via this chlorosulfonic acid is the synthesis of p-acetaminobenzenesulfonyl chloride (P-ASC), in which a large quantity of sulfonic acid is required. This can pose serious environmental