Pathophysiology Essay
Pathophysiology. Thyroid hormones assume a vital role in the normal functioning of the body. Insufficiency in secretion from their source to respond to body needs in the body risks infection of hypothyroidism. They are secreted by the thyroid glands which are located in a close-range to the trachea between the cricoid cartilage and suprasternal notch where they possess two joined lobes by an isthmus. In addition, the thyroid hormones are inconclusive of triodothyronine (T3) and thyroxine (T4) that impact on roughly all cells in the body causing an effect on development, growth and metabolism. Most importantly, thyroid glands normally release this hormone in response to the TSH from the pituitary glands as part of hypothalamic-pituitary thyroid
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Hypothyroidism may develop from high radioiodine dosage, surgical treatment, benign nodular thyroid disease, thyroid cancer and thyroidectomy used in the treatment of thyroid cancer. Besides, it is possible to occur after the outer ray radioactivity for head and neck non-thyroid-related menaces, inclusive of lymphoma. The elderly are more susceptible to thyroid cancer and most patients use therapy to prolong their survival. Henceforth, hypothyroidism control and therapy after prior thyroid cancer are comparatively usual among the elderly persons. A person would be at a high risk of infection with the hypothyroidism when they undergo radioiodine therapy intended for the treatment of the hyperthyroidism of Graves' disease. The mechanism is most likely a radiation-induced reduction in the capability of the thyroid cells to duplicate together with the thyroid autoimmunity existing in such individuals (Garber, 2012).
Drug-induced Hypothyroidism. The type of drugs administered to a subject with hypothyroidism may alter or cause different responses with all factor laid down. For instance, drugs such as amiodarone, cytokines and lithium affect the thyroid function in the body and most cases triggers hypothyroidism especially in the elderly. However, hypothyroidism is also in some cases induced due to over treating it by use of thyroid-blocking drugs (Garber,
Hypothyroidism may develop from high radioiodine dosage, surgical treatment, benign nodular thyroid disease, thyroid cancer and thyroidectomy used in the treatment of thyroid cancer. Besides, it is possible to occur after the outer ray radioactivity for head and neck non-thyroid-related menaces, inclusive of lymphoma. The elderly are more susceptible to thyroid cancer and most patients use therapy to prolong their survival. Henceforth, hypothyroidism control and therapy after prior thyroid cancer are comparatively usual among the elderly persons. A person would be at a high risk of infection with the hypothyroidism when they undergo radioiodine therapy intended for the treatment of the hyperthyroidism of Graves' disease. The mechanism is most likely a radiation-induced reduction in the capability of the thyroid cells to duplicate together with the thyroid autoimmunity existing in such individuals (Garber, 2012).
Drug-induced Hypothyroidism. The type of drugs administered to a subject with hypothyroidism may alter or cause different responses with all factor laid down. For instance, drugs such as amiodarone, cytokines and lithium affect the thyroid function in the body and most cases triggers hypothyroidism especially in the elderly. However, hypothyroidism is also in some cases induced due to over treating it by use of thyroid-blocking drugs (Garber,