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Pantoprazole In Hcl

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Pantoprazole In Hcl
9.1 PRELIMINARY STUDIES:
9.1.1. Identification and Analysis of Drug:
 Determination of λmax of by UV spectroscopy: The λmax of the solution of Pantoprazole was found to be 290 nm on UV spectroscopy.
 Melting point determination of drug:
The melting point of drug was found to be 136±3 ̊C.
 Solubility determination of pantoprazole:
The solubility of drug was determined and it is soluble in water, ethanol and slightly soluble in DCM.
 Solubility determination of excipients:
Excipient Medium Result
EC Water Soluble
EC Ethanol Insoluble
EC Dichloromethane Insoluble

HPMC Water Soluble
HPMC Ethanol Insoluble
HPMC Dichloromethane Soluble

9.1.2 Analytical Method Development:
(1) Calibration curve of Pantoprazole in distilled water …show more content…
.
(2) Calibration curve of Pantoprazole in HCl buffer (290nm) Figure 9.2 calibration curve of Pantoprazole in HCL buffer

9.2 Evaluation of floating microspheres:
9.2.1. Percentage Yield:
Table 9.3 Practical yield of Pantoprazole floating microspheres
Formulation code Practical yield
(mg) Theoretical yield
(mg) Percentage yield (%)
F1 400 650 61.55±2.67
F2 450 700 65.71±1.26
F3 500 750 66.66±1.16
F4 550 800 72.5±2.36
F5 650 850 …show more content…
No. Wavelength cm -1 Interpretation
1 3500-3400 cm -1 O-H hydroxyl group
2 2900-2850 cm -1 C-H alkanes group
3 1150-1100 cm -1 C-O alcohol, ether group

FTIR of HPMC

Table 9.11: FTIR interpretation analysis of HPMC
S. No. Wavelength cm -1 Interpretation
1 3600-3500 cm -1 O-H phenols group
2 2950-2850 cm -1 C-H Alkenes group
3 1400-1300 cm -1 Methyl bonding

FTIR analysis of Pantoprazole + HPMC

Table 9.12: FTIR interpretation analysis of Pantoprazole + HPMC
S. No. Wavelength cm -1 Interpretation
1 3530-3400 cm -1 O-H phenols group
2 3300-3200 cm -1 N-H amides group
3 3000-2910 cm -1 C=C-H alkenes
4 1450-1350 cm -1 Methyl bonding
5 1100-1000 cm -1 C-O alcohol, ether group

FTIR analysis of Pantoprazole Microspheres

Table 9.14: IR interpretation analysis of Pantoprazole Microspheres

S. No. Wavelength cm -1 Interpretation
1 3400-3350 cm -1 O-H phenol group
2 2900-2800 cm -1 C-H alkenes group
3 1100-1000 cm -1 C-O alcohol, ether
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