Opioid Analysis Of Fentanyl

Fentanyl is a synthetic opioid analgesic generally used for the treatment of breakthrough pain in patients with cancer. Since several years, research has focused on preparing fentanyl formulations which can be administered by alternative routes such as sublingual, buccal, transmucosal and transdermal to overcome problem of conventional routes of administration: a) hepatic first pass metabolism and poor bioavailability by oral route, b) delayed onset of action by oral route, c) inconvenience of administration of needle for injection and risks associated with parenteral administration (risk of infection and hypersensitivity reactions) and d) Inability to self administer the treatment by patient or care provider. Several of these formulations