By splitting the needed doses of methadone, forward results were documented: There was no correlation between methadone dose and the baby’s treatment. There was also no difference between the mothers who conceived on methadone, and the ones who conceived off-it. Male babies were more likely to require a treatment. Although in other studies, gender played no role in treatment wise. Also, low serum levels, less than 365 ng/ml, was related to treatment needs. Fetal responded to withdrawal symptoms by increasing in their movement. This hyperactivity was avoided with higher methadone dose. LOS has correlated with the gestational age. Overall studies showed high relationship between dose plan and NAS severity, rather than the dose itself. Therefore, multiple methadone dose plan is helpful in limiting withdrawal symptoms and hyperactivity that baby may suffer from intra-uterinaly. It also, beneficial to maintain proper continuous dose all across the day with no peak negative side effects. In addition, it increases maternal and neonatal recovery, with reducing the severity of NAS. Any opposing studies might differ in the dosing process considering special metabolic status of the pregnant, and intrauterine withdrawal
By splitting the needed doses of methadone, forward results were documented: There was no correlation between methadone dose and the baby’s treatment. There was also no difference between the mothers who conceived on methadone, and the ones who conceived off-it. Male babies were more likely to require a treatment. Although in other studies, gender played no role in treatment wise. Also, low serum levels, less than 365 ng/ml, was related to treatment needs. Fetal responded to withdrawal symptoms by increasing in their movement. This hyperactivity was avoided with higher methadone dose. LOS has correlated with the gestational age. Overall studies showed high relationship between dose plan and NAS severity, rather than the dose itself. Therefore, multiple methadone dose plan is helpful in limiting withdrawal symptoms and hyperactivity that baby may suffer from intra-uterinaly. It also, beneficial to maintain proper continuous dose all across the day with no peak negative side effects. In addition, it increases maternal and neonatal recovery, with reducing the severity of NAS. Any opposing studies might differ in the dosing process considering special metabolic status of the pregnant, and intrauterine withdrawal