Micropapillary Case Study

Micropapillary in situ carcinoma: intraluminal epithelial papillary projections, in contrast to papillary carcinoma, fibrovascular stroma is absent, pure micropapillary in situ carcinoma is associated with foci of microinvasion and multicentricity. Clinging in situ carcinoma: is a type of intraductal carcinoma in which one to two layers of malignant cells lined the ducts periphery.

All types of in situ carcinomas have risk to transform into invasive carcinoma; the risk of invasive carcinoma development is related to cytologic grade of tumor. (58)

2) Lobular carcinoma in situ (LCIS): also be called lobular neoplasia characterized by proliferations of neoplastic cells replacing the normal epithelial of breast lobules, but they don’t grow through the wall of the lobules, LCIS will not always become invasive lobular carcinoma.
(59) Risk of invasive carcinoma development from LCIS is increased.

Diagnosis: Often, LCIS does not cause a tumor that can be felt mostly, LCIS is found when a biopsy is done for another breast problem.

A certain kind of LCIS, called pleomorphic, may be more likely to turn into invasive cancer than most kinds of LCIS. (60) (A) (B)

Fig.22. A & B: Lobular carcinoma in situ. The distended lobules obliterated by small and relatively uniform cells, H & E, X100 and X400.