Medical Imaging, Techniques, Reflection and Evaluation

Only available on StudyMode
  • Download(s) : 54
  • Published : May 4, 2013
Open Document
Text Preview
Breast Cancer Screening in Women with a Familial or Genetic Predisposition The role of MRI

Borstkanker screening bij vrouwen met een familiaire of genetische predispositie De rol van MRI

Cover painting: Heleen Vriesendorp Layout / cover design: Philip de Bruin Printed by: Optima Grafische Communicatie, Rotterdam ISBN: 90-8559-210-0 The studies described in this thesis were supported by grants from the Dutch Health Insurance Council (OG-9803) and Zon MW (6200.0005), and were performed at the department of Medical Oncology, Erasmus MCDaniel den Hoed Cancer Center, Rotterdam in collaboration with the Departments of Radiology, Surgical Oncology, Clinical Genetics and Public Health of the Erasmus MC Rotterdam, the Netherlands Cancer Institute, Amsterdam, the Leiden University Medical Center, the University Medical Center Nijmegen, the University Medical Center, University of Groningen, the VU University Medical Center, Amsterdam. Publication of this thesis was financially supported by: GlaxoSmithKline, Amgen B.V. Breda, Roche Nederland B.V., Siemens Nederland B.V., AstraZeneca © Mieke Kriege 2006 No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the author.

Breast Cancer Screening in Women with a Familial or Genetic Predisposition The role of MRI

Borstkanker screening bij vrouwen met een familiaire of genetische predispositie De rol van MRI

Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van rector magnificus Prof.dr. S.W.J. Lamberts en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 15 november 2006 om 9.45 uur door Annemieke Germa Kriege geboren te Wassenaar

Promotiecommissie Promotor Prof.dr. J.G.M. Klijn Overige Leden Dr. H.J. de Koning Prof.dr. G.P. Krestin Prof.dr. M.F. Niermeijer Copromotor Dr. C.T.M. Brekelmans

CONTENTS

CHAPTER 1 CHAPTER 2

Introduction MRI screening for breast cancer in women with a familial or genetic predisposition

7 23

Imaging Decisions, 9: 11-18 (2005)
CHAPTER 3 MRI screening for breast cancer in women with a familial or genetic predisposition: design of the Dutch national study (MRISC) 37

Familial Cancer, 1: 163-168 (2001)
CHAPTER 4 Efficacy of MRI and mammography for breast cancer screening in women with a familial or genetic predisposition 47

New England Journal of Medicine, 351: 427-437 (2004)
CHAPTER 5 Differences between first and subsequent rounds of the MRISC breast cancer screening program for women with a familial or genetic predisposition 63

Cancer, 106: 2318-26 (2006)
CHAPTER 6 Tumor characteristics and detection method in the MRISC screening program for the early detection of hereditary breast cancer 77

Breast Cancer Research and Treatment (2006), in press
CHAPTER 7 Factors affecting sensitivity and specificity of screening mammography and MRI in women with an inherited risk for breast cancer 87

Breast Cancer Research and Treatment (2006), in press
CHAPTER 8 Hereditary breast cancer growth rates and its impact on screening policy 103

European Journal of Cancer, 41: 1610-1617 (2005)
CHAPTER 9 Discussion and concluding remarks Summary/Samenvatting Dankwoord Curriculum Vitae List of publications 117 129 137 139 141

CHAPTER 1

Introduction

Introduction

|9

INTRODUCTION
Breast cancer is the most common cancer in females. Worldwide more than 1 million new cases are diagnosed each year and nearly 600,000 women die from breast cancer.1 The incidence varies over the world and is highest in the USA, followed by northern Europe. Between 1997 and 2001, each year, in the USA there were diagnosed on average 135 breast cancers per 100,000 women and 27 breast cancer-related deaths per 100,000 women occurred. In total 13% (1:8) of the women in the USA will be...
tracking img