Medical Cannabis Research (Ca)

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CENTER FOR MEDICINAL
CANNABIS RESEARCH
Report to the Legislature and Governor of the State of California presenting findings pursuant to SB847 which created the CMCR and provided state funding

Director:

Igor Grant, M.D.

University of California, San Diego
Co-Directors:

J. Hampton Atkinson, M.D.
Andrew Mattison, Ph.D.*

University of California, San Diego

Thomas J. Coates, Ph.D.

University of California, Los Angeles
*Deceased

Prepared February 11, 2010 | University of California | www.cmcr.ucsd.edu

Objective
In 1999, the California legislature passed and Governor Gray Davis signed SB847, which commissioned the University of California to establish a scientific research program to expand the public scientific knowledge on purported therapeutic usages of marijuana.

We hereby submit this report of our scientific findings pursuant to this objective.

W W W.C M C R .U C S D. E D U • FE B R UA RY 11, 2 010

Table of Contents
Executive Summary .......................................................................................................... 2 Summary of Results to Date ........................................................................................................2 Other CMCR Activities ...................................................................................................................3 Conclusion .......................................................................................................................................4 Mission Statement ............................................................................................................ 4 Scientific and Legislative Precursors of the CMCr ...................................................... 5 Discovery of Cannabis Receptors in the Brain .........................................................................5 Scientific Reports ............................................................................................................................5 Legislative Origins ..........................................................................................................................5 CMCr review Process....................................................................................................... 6 CMCr Vision for Cannabis Therapeutics research...................................................... 7 Stage I: Smoked Cannabis............................................................................................................7 Stage II: Non-Smoked Preparations ...........................................................................................7 Stage III: Molecules To Target Endocannabinoid System .....................................................7 Overview of research Program ...................................................................................... 8 Studies in Pain and Other Neurologic Conditions ..................................................................8 Synopsis of CMCr Published Clinical Study results ................................................. 10 “ The Effect of Cannabis on Neuropathic Pain in HIV-Related Peripheral Neuropathy” ................................................................................................................................. 10 “Placebo-Controlled, Double Blind Trial of Medicinal Cannabis in Painful HIV Neuropathy” ................................................................................................................................. 10 “A Double-Blind, Placebo-Controlled Crossover Trial of the Antinociceptive Effects of Smoked Marijuana on Subjects with Neuropathic Pain“.............................................. 11 “Analgesic Efficacy of Smoked Cannabis” ............................................................................. 11 “Short-Term Effects of Cannabis Therapy on Spasticity in Multiple-Sclerosis” ............. 12 “Vaporization as a ‘Smokeless’ Cannabis Delivery...
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