The type of liposome used does not make a difference in the percent of RIF entrapped but the type of lipid used does. Phosphatidycholine (PC) based lipids entrap significantly less RIF than saturated lipids. When Chol is used within the lipid it will displace the RIF causing the amount of RIF in the liposome to decrease. (Marco, Mourtas, Klepetsans, Fadda, & Antimisiaris, 2007)After nebulizing the liposomes the nebulizing efficiency was 70% or higher for all liposomes. The only significant difference was that 50%-mol Chol distearoyloglycero-PC (DSPC) had a nebulization efficiency of 32-43%. This finding made it clear that rigid liposomes are not ideal for nebulization. (Marco et al., …show more content…
Nebulizing liposomes would allow for the delivery of drugs to be much more precise and would decrease the risk of side effects when compared to other methods. (Marco et al., 2007) Using liposomes with a pH gradient to treat an overdose of cardiovascular medications would have lesser side effects than fat emulsion injections. The pH gradient would entrap the drug as the acidity level naturally neutralized. (Bertrand et al., 2010) Liposomes will be a very useful treatment option for a large range of problems in the near future as it is researched