Human Genetic Modofication

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  • Topic: Kidney, Chronic kidney disease, DNA
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Gene Therapy for Renal Diseases and Transplantation

Contributions to Nephrology
Vol. 159

Series Editor

Claudio Ronco

Vicenza

Gene Therapy for Renal Diseases and Transplantation
Volume Editors

Ariela Benigni Bergamo Giuseppe Remuzzi Bergamo

15 figures, 4 in color, and 6 tables, 2008

Basel · Freiburg · Paris · London · New York · Bangalore · Bangkok · Shanghai · Singapore · Tokyo · Sydney

Contributions to Nephrology
(Founded 1975 by Geoffrey M. Berlyne)

Ariela Benigni
Department of Molecular Medicine Mario Negri Institute for Pharmacological Research Via Gavazzeni, 11 IT-24125 Bergamo (Italy) Library of Congress Cataloging-in-Publication Data

Giuseppe Remuzzi
Mario Negri Institute for Pharmacological Research Via Gavazzeni, 11 IT-24125 Bergamo (Italy)

Gene therapy for renal diseases and transplantation / volume editors, Ariela Benigni, Giuseppe Remuzzi. p. ; cm. – (Contributions to nephrology, ISSN 0302-5144 ; v. 159) Includes bibliographical references and indexes. ISBN 978-3-8055-8505-7 (hard cover : alk. paper) 1. Kidneys–Diseases–Gene therapy. 2. Kidneys–Transplantation–Genetic aspects. 3. Graft rejection–Prevention. 4. Gene therapy. I. Benigni, Ariela. II. Remuzzi, Giuseppe. III. Series. [DNLM: 1. Kidney Diseases–therapy. 2. Gene Therapy. 3. Graft Rejection–therapy. 4. Kidney Transplantation. W1 CO778UN v.159 2008 / WJ 300 G326 2008] RC903.G43 2008 616.6 1042–dc22 2008006529

Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and Index Medicus. Disclaimer. The statements, options and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. © Copyright 2008 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISSN 0302–5144 ISBN 978–3–8055–8505–7

Contents

VII Preface
Benigni, A.; Remuzzi, G. (Bergamo)

1 Renal Diseases as Targets of Gene Therapy
Phillips, B.; Giannoukakis, N.; Trucco, M. (Pittsburgh, Pa.)

13 Nonviral Gene Delivery
Akita, H.; Harashima, H. (Sapporo/Saitama)

30 Retrovirus Vectors
Lech, P.; Somia, N.V (Minneapolis, Minn.) .

47 Adenovirus Vectors for Renal-Targeted Gene Delivery
Appledorn, D.M.; Seregin, S.; Amalfitano, A. (East Lansing, Mich.)

63 Adeno-Associated Virus Vectors: Versatile Tools for in vivo Gene Transfer Zentilin, L.; Giacca, M. (Trieste)

78 RNA Interference in Research and Therapy of Renal Diseases Rácz, Z.; Hamar, P. (Budapest)

96 Gene Therapy for Acute Renal Failure
Torras, J.; Cruzado,...
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