Hib Vaccination Essay
As we know Hib and NTHi strains cause most of the H. influenzae diseases. (Immunisation Handbook 2011 p: 155-166) and (Klein JO, 1997; Murphy TF 2003). Vaccination remains the valuable effect in the prevention of infectious diseases. (Cohen J and Marshall E, 2001; Curtiss R ,2002 ; Hunter RL 2002). Virulence factors with no comprehensive and variation gene sequence that are capable of creating a powerful and protective antibody response, could be used as H. influenzae vaccine candidates (Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition, 2015, p: 119). Given the important role of the structural polysaccharide (PRP) of Hib in its virulence and immunity, this virulence factor has already been used as a vaccine candidate against Hib (Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition, 2015, p: 119).
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1999] The PRP vaccines (Adams WG, et al. 1993) do not protect children against infections caused by NTHi strains; therefore, for producing a protective vaccine against both Hib and NTHi strains, PRP should be applied with an immunogenic protein carrier of NTHi such as its conserved surface lipoproteins. Some surface proteins of H. influenzae including auto-transporters (such as Hap, HMW1/HMW2, Hia, Hsf, P2, P5, D, E) are involved in adherence to epithelial cells [Poolman JT, et al 2000] , [Ronander E, et al. 2008] that have been studied previously [Brinton CC et
1999] The PRP vaccines (Adams WG, et al. 1993) do not protect children against infections caused by NTHi strains; therefore, for producing a protective vaccine against both Hib and NTHi strains, PRP should be applied with an immunogenic protein carrier of NTHi such as its conserved surface lipoproteins. Some surface proteins of H. influenzae including auto-transporters (such as Hap, HMW1/HMW2, Hia, Hsf, P2, P5, D, E) are involved in adherence to epithelial cells [Poolman JT, et al 2000] , [Ronander E, et al. 2008] that have been studied previously [Brinton CC et