Hemophilia a Summary

Topics: Coagulation, Blood, Platelet Pages: 4 (933 words) Published: January 28, 2013
-Hemophilia A is an inherited disorder in which one of the proteins needed to form blood clots is missing or reduced. This lacking protein is known as blood clotting factor 8. Without F8, the blood cannot clot properly to stop bleeding and can result in excessive bleeding or disabilities.

Hemophilia A
-When blood is not able to clot and allow wounds to heal, this is a result of Hemophilia A
Symptoms Include:
-Prolonged bleeding from cuts
-Excessive nose bleeds
-Many large bruisings
-1 in 5,000 males are affected

Blood Coagulation
-Blood coagulation is the defensive process that causes blood to clot and helps prevent excessive blood loss when blood vessels are injured. -Coagulation is a complex process that involves 20 to 30 components, called blood coagulation factors, and a series of complex chemical reactions. -When a blood vessel is injured, platelets in the area of the damage clump together and stick to the edges of the cut to begin the coagulation process. -Platelets are fragments of cells containing clotting factors and play a major role in blood clotting. -These clotting factors help platelets stick together and activate fibrin. (These clotting factors combine with a protein called prothrombin in a reaction that converts prothrombin to thrombin. Thrombin then converts fibrinogen (a protein present in plasma) into long, sticky threads of another protein called fibrin) -The fibrin forms a mesh-like net over the opening and traps red blood cells as they try to leak out of the cut. -As the clot hardens, it forms a protective seal over the cut so that the injury can heal and the vessel wall can be restored.

Factor 8
-One specific intrinsic clotting cofactor that stabilizes the fibrin clot is Factor 8. -F8 is activated by thrombin in the presence and is a cofactor in the activation of factor X (WHAT DOES X DO??) -Ultimately Factor F8 cross-links fibrin polymers solidifying the clot. -Without this coagulation factor, vessels...
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