Medical student Sunita is driven by curiosity to study the case of Sanjay Singhania, who is afflicted with short-term memory loss. She wants to investigate the curious case of Sanjay Singhania , a (former) notable city businessman, who is reported to have anterograde amnesia. Her professor denies access to Sanjay's records as it is currently under criminal investigation. Sunita, nonetheless, decides to investigate the matter herself.
Sanjay is introduced as he brutally murders a man. He takes a Polaroid picture of the man, and writes on it "done". It is revealed that Sanjay has anterograde amnesia where he loses his memory every 15 minutes. Sanjay uses a system of photographs, notes, and tattoos on his body to recover his memory after each cycle. It is revealed that Sanjay is ultimately out to avenge the death of his sweetheart Kalpana, and that he is systematically killing the people who were responsible for it. His main target is "Ghajini", a notable social personality in the city.
Police Inspector Arjun Yadav, on the case of the serial murders, tracks Sanjay down to his flat and attacks and disables him. Yadav finds two diaries where Sanjay has chronicled the events of 2005 and 2006. The film flashes back to 2005 as Yadav reads the diary. Sanjay Singhania is shown as the owner of the Air Voice mobile telephone company. In the course of his business, Sanjay sends his men to meet Kalpana, a struggling model, about putting up a billboard above her apartment. The owner of Kalpana's advertising firm misinterprets this as a romantic advance, and in view of a possible lucrative Air Voice ad campaign and other benefits, encourages Kalpana to accept the overture. Kalpana thinks of this as an innocent prank that may fetch her better modeling work, and decides to play out the charade as Sanjay's girlfriend. As soon as Sanjay knows of this matter, he decides to confront Kalpana but falls in love with her on first sight. Thus, he introduces himself as Sachin....
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