Gene Therapy: Future Perspectives And Ethics
Advantages of Gene therapy: Future Perspectives and Ethics
Gene Therapy History
In the 80s, advances in molecular biology have allowed the human genes were cloned and sequenced. Scientists looked for a method to facilitate the production of proteins - such as insulin - viewed introducing human genes into the DNA of bacteria. Bacteria, genetically modified, then began to produce the corresponding protein, which could be collected and injected into people who could not produce naturally. After, on September 14 of 1990, researchers at the National Institutes of Health in the United States, conducted the first gene therapy approved in Ashanti DeSilva, 4 years old, who was born with a rare genetic disease called Severe Combined Immunodeficiency (SCID), she did not have a healthy …show more content…
(2012). AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation. Science Translational Medicine, 4 (140), pp. 140ra87
Kelly, E. B. (2007). Gene therapy. (1st ed., Vol. 1, pp. 4-192). Westport, Conn: Greenwood Press.
Kimmelman, J. (2010). Gene transfer and the ethics of first-in-human research: Lost in translation. (1st ed., Vol. 1, pp. 1-205). Cambridge, NY: Cambridge University Press. Retrieved from https://www.library.yorku.ca/find/Record/2465972
MacLaren, R.E., Groppe, M., Barnard, A.R., Cottriall, C.L., Tolmachova, T., Seymour, L., Clark, K.R., During, M.J., Cremers, E.P.M., Black, G.C.M., Lotery, A.J., Downes, S.M., Webster, A.R., & Seabra, M.C. (2014). Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial. The Lancet, pp. 1-9. Published online January 16, 2014 http://dx.doi.org/10.1016/S0140-6736(13)62117-0
Torjesen, I. (2014). Gene therapy inherited blindness shows promise in first clinical trial. BMJ,
Gene Therapy History
In the 80s, advances in molecular biology have allowed the human genes were cloned and sequenced. Scientists looked for a method to facilitate the production of proteins - such as insulin - viewed introducing human genes into the DNA of bacteria. Bacteria, genetically modified, then began to produce the corresponding protein, which could be collected and injected into people who could not produce naturally. After, on September 14 of 1990, researchers at the National Institutes of Health in the United States, conducted the first gene therapy approved in Ashanti DeSilva, 4 years old, who was born with a rare genetic disease called Severe Combined Immunodeficiency (SCID), she did not have a healthy …show more content…
(2012). AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation. Science Translational Medicine, 4 (140), pp. 140ra87
Kelly, E. B. (2007). Gene therapy. (1st ed., Vol. 1, pp. 4-192). Westport, Conn: Greenwood Press.
Kimmelman, J. (2010). Gene transfer and the ethics of first-in-human research: Lost in translation. (1st ed., Vol. 1, pp. 1-205). Cambridge, NY: Cambridge University Press. Retrieved from https://www.library.yorku.ca/find/Record/2465972
MacLaren, R.E., Groppe, M., Barnard, A.R., Cottriall, C.L., Tolmachova, T., Seymour, L., Clark, K.R., During, M.J., Cremers, E.P.M., Black, G.C.M., Lotery, A.J., Downes, S.M., Webster, A.R., & Seabra, M.C. (2014). Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial. The Lancet, pp. 1-9. Published online January 16, 2014 http://dx.doi.org/10.1016/S0140-6736(13)62117-0
Torjesen, I. (2014). Gene therapy inherited blindness shows promise in first clinical trial. BMJ,