Felodipine Essay

Felodipine is a vasoselective calcium channel antagonist of the dihydropyridine class used in the management of hypertension. It is chemically described as ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimetylpyridine-3,5-di-carboxylate. Estimation of felodipine in biological samples and human plasma has been reported by gas chromatographic (GC) (Soons et al 1990) and liquid chromatographic (LC) methods. Estimation and separation of the metabolites of felodipine in biological samples have been identified by liquid chromatographic methods. Reversed phase liquid chromatographic (RPLC) and spectrophotometer methods are commonly used methods to determine felodipine content in pharmaceuticals (Sridevi et al 2011). Felodipine reversibly competes with nitrendipine and/or other calcium channel blockers for
Generally, calcium antagonists are important in the treatment of hypertension. Among all known hypertensive agents dihydropyridine derivatives (DHP) have gained the most approval. Therefore, selective, sensitive analytical methods for the quantitative evaluation of the drugs and their metabolites are important for the successful conduct of preclinical and/or bio-pharmaceutical and clinical pharmacology studies. Bio-analytical method validation for paracetamol drug includes the parameters such as accuracy, precision, selectivity, sensitivity, reproducibility and sensitivity. All this validation methods are applicable to bio-analytical methods such as Gas Chromatography and High Performance Liquid Chromatography. Unfortunately the most undesirable feature of drugs containing the DHP (dihydropyridine) group is high sensitivity to light .Such drugs are regarded as photo labile. Therefore the photo stability testing has become an important stage of new drug design, production and