Duchene’s Muscular Dystrophy and Amyotrophic Lateral Sclerosis
DMD and ALS Assignment |Last Name: Megan Robbins-Colwell|
In this assignment you will compare DMD and ALS. Fill in the table below using information from the book and websites. Research at least 2 new therapies for each disease. List the complete URLs of the websites where you found information. |DMD|ALS|Early symptoms|· Shoulder, Upper Arm, Hip, and Thigh muscle weakness|· Muscle twitching· Weakness in arm or leg· Slurred speech|Late symptoms|· Difficulty in rising from sitting or lying position, climbing stairs, maintaining balance, and raising arms.|· Loss of function in the muscles needed for movement, speech, eating, and breathing.|Causes|· Genes used to make protective proteins for muscle fibers are defective|· Nerve cells controlling muscle movement gradually die.|Current therapies (at least 2 for each)|· Moderate dose corticosteroids· After load reduction· Daily stretching exercises· Noninvasive positive pressure ventilation |· Riluzole/Rilutek for slowing of ALS progression· Physical/Occupational/Speech therapy|New treatments (at least 2 for each)|· Gene replacement therapy· Agents that modify: dystrophic expression, increase muscle growth, regeneration, and modulate inflammatory responses|· Transplanting neural stem cells in to various levels in the spinal cord to slow the disease progression and improve motor function and breathing, · Transplantation of protective molecules triggers the host cells to produce their own protective molecules.|In a brief paragraph, compare the effects of and therapies for these diseases. What are the similarities and differences?The therapies for both DMD and ALS are similar in the fact that they help to prolong the individual’s function and quality of life. The corticosteroids, after load reduction, and stretching exercises for Duchene’s Muscular Dystrophy increase muscle strength. The NPPV is used when diaphragm muscles become weak to 1. let the patient rest, keeping them from going into respiratory failure and 2. work
In this assignment you will compare DMD and ALS. Fill in the table below using information from the book and websites. Research at least 2 new therapies for each disease. List the complete URLs of the websites where you found information. |DMD|ALS|Early symptoms|· Shoulder, Upper Arm, Hip, and Thigh muscle weakness|· Muscle twitching· Weakness in arm or leg· Slurred speech|Late symptoms|· Difficulty in rising from sitting or lying position, climbing stairs, maintaining balance, and raising arms.|· Loss of function in the muscles needed for movement, speech, eating, and breathing.|Causes|· Genes used to make protective proteins for muscle fibers are defective|· Nerve cells controlling muscle movement gradually die.|Current therapies (at least 2 for each)|· Moderate dose corticosteroids· After load reduction· Daily stretching exercises· Noninvasive positive pressure ventilation |· Riluzole/Rilutek for slowing of ALS progression· Physical/Occupational/Speech therapy|New treatments (at least 2 for each)|· Gene replacement therapy· Agents that modify: dystrophic expression, increase muscle growth, regeneration, and modulate inflammatory responses|· Transplanting neural stem cells in to various levels in the spinal cord to slow the disease progression and improve motor function and breathing, · Transplantation of protective molecules triggers the host cells to produce their own protective molecules.|In a brief paragraph, compare the effects of and therapies for these diseases. What are the similarities and differences?The therapies for both DMD and ALS are similar in the fact that they help to prolong the individual’s function and quality of life. The corticosteroids, after load reduction, and stretching exercises for Duchene’s Muscular Dystrophy increase muscle strength. The NPPV is used when diaphragm muscles become weak to 1. let the patient rest, keeping them from going into respiratory failure and 2. work