Dapsone Research Paper

Dapsone, an antibacterial is primarily and effectively useful in the leprosy treatment which is also used in combination with Rifampicin and Clofazimine for the treatment of Mycobacterium leprae infections(leprosy) [1-4], malaria[5-7] and pneumocystis pneumonia(PCP) [8-10]. Specifically, Dapsone stops the bacterial dihydrofolic acid synthesis through the process of binding itself in the active site of the enzyme named 6-hydroxymethyl-7, 8-dihydropteroate synthase (DHPS), which takes part in the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7, 8-dihydropteroate and pyrophosphate [11]. Moreover Dapsone competes with para-aminobenzoate on the active site of DHPS and inhibits the