Cystic Disorders: Cystic Fibrosis
Introduction:
Cystic fibrosis (CF) is the most common inherited disorder which results from mutation of cystic fibrosis transmembrane regulator (CFTR) gene. It occurs approximately in one of every 2500 live births in the white population(1) ; and characterized by abnormal thick viscous secretions in the respiratory, gastrointestinal and genitourinary tracts together with chronic suppurative endobronchial infection(2), resulting in death or lung transplantation in more than 500 patients every year in the United States(3). Incidence of CF is lower among African Americans (1in 15000)(4)and Asians (1in 32000)(5).
However, the incidence in population of other ethnic backgrounds including Egyptians has not been fully established, with very few published
Cystic fibrosis (CF) is the most common inherited disorder which results from mutation of cystic fibrosis transmembrane regulator (CFTR) gene. It occurs approximately in one of every 2500 live births in the white population(1) ; and characterized by abnormal thick viscous secretions in the respiratory, gastrointestinal and genitourinary tracts together with chronic suppurative endobronchial infection(2), resulting in death or lung transplantation in more than 500 patients every year in the United States(3). Incidence of CF is lower among African Americans (1in 15000)(4)and Asians (1in 32000)(5).
However, the incidence in population of other ethnic backgrounds including Egyptians has not been fully established, with very few published