INTRODUCTION
1.1 INTRODUCTION
Calcium is the largest mineral in the human body, where it plays an important role in absorption and the releasing of calcium in the body is through the intestinal and kidney. The calcium in the body is controlled by hormones and vitamins (Takano et al). The three major components that involve in the controller the calcium is parathyroid hormone (PTH), calcitonin and Vitamin D. The consistent the calcium in the body from despite variation in-take and excretion also need help by others hormones to balance the homeostasis of calcium (Caprita, Caprita, & Cretescu, 2013).
Calcium in a human body can be found in three distinct fractions which are related to one and another as an ionized or free calcium, the complex calcium and non-diffusible calcium where the calcium bound to plasma protein (Wills, Lewin, & Hospital, 1971). The level of calcium is closely regulated by the normal total calcium and normal ionized calcium. The total amount of calcium in the body varies with the level of serum albumin, a protein to bind with calcium.
A biological effect of calcium is measured by the amount of ionized calcium, total calcium. The calcium is not a dependent parameter. Calcium is a measurement of the …show more content…
Since conditions tend to change ionized calcium independently of total calcium, ionized calcium is one of the preferred methods of calcium binding to albumin. In this case, the measurement of ionized calcium referred to detect hypocalcaemia (Hannan & Thakker, 2013). The first step to assess patients with hypocalcaemia is the measurement of the concentration of serum albumin. Where the calcium is bound to proteins, primarily albumin, therefore total calcium concentrations in patients with low levels of serum albumin or higher may not be appropriate for measured the ionized