Analysis Of Cystic Fibrosis
Cystic Fibrosis is a severe inherited disease that affects 30,000 children each year in the United States. As the disease is inherited, it is created by a mutated protein that regulates the equilibrium of salt in each cell. This mutated protein affects the normal function of Epithelial Cells or sweat cells and cells that line the lungs. This defected epithelial cell creates a thick and sticky mucus that can impair the flow of oxygen to the lungs. CF is a chronic disease that can affect every aspect of the person’s life.
In 1938 Dr. Dorothy Andersen distinguished Cystic Fibrosis from Celiac Disease. While both diseases affect the digestive system, Cystic Fibrosis mainly affects the Respiratory system. When CF was first acknowledged, a pathological …show more content…
While those who are diagnosed with CF generally have issues breathing, those who are also surrounded by tobacco smoke and pollution breathing increasingly worsens. Smoking itself increase the likelihood of continuous lung infection, but combined with CF it allows the entrance of more infections. The fine particles in air pollution enter the patient’s lungs as they breath in, allowing them to become stuck in the thick mucus. When the particles begin the mix with the mucus it allows for more infections to occur. While the Cilia inside the lungs is coated with the thick mucus, it is impossible for it to do its job, cleaning the lungs. While the environment affects the state of the disease, faulty genes create …show more content…
The faulty gene is found on chromosome pair 7, where one gene from each parent is given to the child. There are 1400 mutations of the CFTR that may cause CF. Over 70% of the people who are diagnosed with the disease are diagnosed because they inherited the Delta F508 gene from both parents. The CFTR or cystic fibrosis transmembrane conductance regulator gene directs the body’s epithelial cells to create a mutated form of CFTR. When the CFTR is defective, the cells can not regulate the chloride that passes in and out of the cell. This disruption causes the balance of salt and water in each cell that generally allow for a thin coating of fluid to be inside the lungs to be
In 1938 Dr. Dorothy Andersen distinguished Cystic Fibrosis from Celiac Disease. While both diseases affect the digestive system, Cystic Fibrosis mainly affects the Respiratory system. When CF was first acknowledged, a pathological …show more content…
While those who are diagnosed with CF generally have issues breathing, those who are also surrounded by tobacco smoke and pollution breathing increasingly worsens. Smoking itself increase the likelihood of continuous lung infection, but combined with CF it allows the entrance of more infections. The fine particles in air pollution enter the patient’s lungs as they breath in, allowing them to become stuck in the thick mucus. When the particles begin the mix with the mucus it allows for more infections to occur. While the Cilia inside the lungs is coated with the thick mucus, it is impossible for it to do its job, cleaning the lungs. While the environment affects the state of the disease, faulty genes create …show more content…
The faulty gene is found on chromosome pair 7, where one gene from each parent is given to the child. There are 1400 mutations of the CFTR that may cause CF. Over 70% of the people who are diagnosed with the disease are diagnosed because they inherited the Delta F508 gene from both parents. The CFTR or cystic fibrosis transmembrane conductance regulator gene directs the body’s epithelial cells to create a mutated form of CFTR. When the CFTR is defective, the cells can not regulate the chloride that passes in and out of the cell. This disruption causes the balance of salt and water in each cell that generally allow for a thin coating of fluid to be inside the lungs to be