Allergic Conjunctivitis Essay
Link between allergic conjunctivitis and migraine
Introduction:
Allergic conjunctivitis (AC) is a group of common diseases that affects the ocular surface and is usually associated with type 1 hypersensitivity reactions with a prevalence of childhood AC of 15–40%. The ocular symptoms of AC may also affect the clinical burden of comorbid allergic diseases. In children, migraine is a common, multifactorial, recurrent neurovascular headache characterized by severe headache, nausea, vomiting, photophobia and lacrimation.
The ocular autonomic symptoms of migraine, likelacrimation, conjunctival injection, eyelid edema and soreness, are similar to the symptoms of AC. Studies that addressed childhood AC and subsequent migraine risks were limited.
Objective: …show more content…
Author hypothesized that children with AC would increase the future risk of migraine.
Method:
Population-based cohort study, data were obtained from National Health Insurance Research Database (NHIRD). #09 138 children with AC and 309 138 non-AC controls were included in this between 2000 and 2007. By 2008 end, the incidences of migraine in both cohorts, and the AC-to-non-AC cohort hazard ratios (HRs) were measured. Statistical analysis was carried out where P<0.001) compared with non-AC children. Fig 1 Figure 1: The Kaplan–Meier analysis of probability free of migraine for allergic conjunctivitis (AC) cohort compared with non-AC cohort.
Adapted from: Wang IC et al.2016
• The incidence of migraine was 1.92-fold higher in the AC cohort than in the non-AC cohort.
• A sex specific analysis showed that the prevalence of migraine was approximately twofold higher in girls in both cohorts.
• The risk of migraine gradually increased since the first year of AC diagnosis and increased to the highest level when followed for 4–5 years, following which the risk decreased with
Introduction:
Allergic conjunctivitis (AC) is a group of common diseases that affects the ocular surface and is usually associated with type 1 hypersensitivity reactions with a prevalence of childhood AC of 15–40%. The ocular symptoms of AC may also affect the clinical burden of comorbid allergic diseases. In children, migraine is a common, multifactorial, recurrent neurovascular headache characterized by severe headache, nausea, vomiting, photophobia and lacrimation.
The ocular autonomic symptoms of migraine, likelacrimation, conjunctival injection, eyelid edema and soreness, are similar to the symptoms of AC. Studies that addressed childhood AC and subsequent migraine risks were limited.
Objective: …show more content…
Author hypothesized that children with AC would increase the future risk of migraine.
Method:
Population-based cohort study, data were obtained from National Health Insurance Research Database (NHIRD). #09 138 children with AC and 309 138 non-AC controls were included in this between 2000 and 2007. By 2008 end, the incidences of migraine in both cohorts, and the AC-to-non-AC cohort hazard ratios (HRs) were measured. Statistical analysis was carried out where P<0.001) compared with non-AC children. Fig 1 Figure 1: The Kaplan–Meier analysis of probability free of migraine for allergic conjunctivitis (AC) cohort compared with non-AC cohort.
Adapted from: Wang IC et al.2016
• The incidence of migraine was 1.92-fold higher in the AC cohort than in the non-AC cohort.
• A sex specific analysis showed that the prevalence of migraine was approximately twofold higher in girls in both cohorts.
• The risk of migraine gradually increased since the first year of AC diagnosis and increased to the highest level when followed for 4–5 years, following which the risk decreased with