Activity of Gastrointestinal Smooth Muscle Worksheet

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Activity of Gastrointestinal Smooth Muscle: Worksheet

Please Ensure That You Have Completed The Calculations In Tables 1-3 Before You Answer The Worksheet Questions

Table 1. The effects of phentolamine and atropine on the contractile response to nerve stimulation (20 Hz) in the isolated rabbit ileum

| |Contraction amplitude |Contraction amplitude with the |Effect of nerve stimulation on the contraction amplitude | | |pre-nerve stimulation |maximum response to nerve | | | | |stimulation |PLEASE SHOW YOUR CALCULATIONS | | |Maximum – Minimum |Maximum – Minimum |Express the effect of nerve stimulation as % change (from | | |= 3.75 mV |= 2.00 mV |pre-nerve stimulation to maximum response to nerve | | | | |stimulation): | | | | | | | | | |= 53.3 % | |with phentolamine |Maximum – Minimum |Maximum – Minimum |Express the effect of nerve stimulation as % change (from | | |= 4.40 mV |= 2.35 mV |pre-nerve stimulation to maximum response to nerve | | | | |stimulation): | | | | |= 53.4 % | | |Maximum – Minimum |Maximum – Minimum |Express the effect of nerve stimulation as % change (from | |with atropine |= 4.30 mV |= 2.40 mV |pre-nerve stimulation to maximum response to nerve | | | | |stimulation): | | | | |= 55.8 % |

Table 2. The effects of phentolamine and atropine on the contractile response to noradrenaline in the isolated rabbit ileum

| | |Contraction amplitude with the | | | |Contraction amplitude |maximum response to |Effect of noradrenaline on the contraction amplitude | | |pre-noradrenaline |noradrenaline | | | | | |PLEASE SHOW YOUR CALCULATIONS | | |Maximum – Minimum |Maximum – Minimum |Express the effect of noradrenaline as % change (from | | |= 8.20 mV |= 4.50 mV |pre-noradrenaline to maximum response to noradrenaline): | | | | |= 55% | |with phentolamine |Maximum – Minimum |Maximum – Minimum |Express the effect of noradrenaline as % change (from | | |= 4.50 mV |=...
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