Medical Immunology

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  • Topic: Immune system, Innate immune system, Toll-like receptor
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MEDICAL IMMUNOLOGY & SEROLOGY

Terence L. Eday, RMT, MT(ASCPi), MPH
College of Medical Technology / Medical Laboratory Science

University of Perpetual Help System DALTA

Historical Perspective
• 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled • 1798, Edward Anthony Jenner, Smallpox vaccination • 1862, Ernst Haekel, Recognition of phagocytosis

• 1877, Paul Erlich, recognition of mast cells

Historical Perspective
• 1879, Louis Pasteur, Attennuated chicken cholera vaccine development • 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination • 1885, Pasteur discovered therapeutic vaccination; first report of live “attenuated” vaccine for rabies

Historical Perspective
• 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) • 1888, George Nuttall, Bactericidal action of blood • 1890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity • 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity • 1894, Richard Pfeiffer, Bacteriolysis

Historical Perspective (1 of 6 )
• 1895, Jules Bordet, Complement and antibody activity in bacteriolysis • 1900, Paul Ehrlich, responsible for the antibody formation theory • 1901, Karl Landsteiner, A, B, and O • 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors • 1902, Paul Portier & Charles Richet, Anaphylaxis

Historical Perspective (1 of 6 )
• 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity • 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin • 1906, Clemens von Pirquet, coined the word allergy • 1907, Svante Arrhenius, coined the term immunochemistry

Historical Perspective
• 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups • 1910, Peyton Rous, Viral immunology theory

• 1914, Clarence Little, Genetics theory of tumor transplantation • 1915-20, Leonll Strong & Clarence Little, Inbred mouse strains

Historical Perspective
• 1917, Karl Landsteiner, Haptens
• 1921, Carl Prausnitz & Heinz Kustner, Cutaneous reactions • 1924, L. Aschoff, Reticuloendothelial system • 1926, Loyd Felton & GH Bailey, Isolation of pure antibody preparation • 1938, John Marrack, Antigen-antibody binding hypothesis

Historical Perspective
• 1936, Peter Gorer, Identification of the H2 antigen in mice • 1940, Karl Landsteiner & Alexander Weiner, Identification of the Rh Antigens • 1941, Albert Coons, Immunofluorescence technique • 1942, Jules Freund & Katherine McDermott, Adjuvants

• 1942, Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis)

Historical Perspective
• 1944, Peter Medwar, Immunological hypothesis of allograft rejection • 1948, Astrid Fagraeus, Demonstration of antibody production in plasma B cells • 1948, George Snell, Congenic mouse lines • 1949, Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesis

Historical Perspective
• 1950, Richard Gershon and K Kondo, Discovery of supressor T cells • 1952, Ogden and Bruton, discovery of agammaglobulinemia (antibody immunodeficiency) • 1953, Morton Simonsen and WJ Dempster, Graft-versus-host reaction

• 1953, James Riley & Geoffrey West, Discovery of histamine in mast cells

Historical Perspective
• 1953, Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis • 1955-1959, Niels Jerne, David Talmage, Macfarlane Burnet, Clonal Selection Theory • 1957, Ernest Witebsky et all., Induction of autoimmunity in animals • 1957, Alik Isaacs & Jean Lindemann, Discovery of interferon (cytokine)

Historical Perspective
• 1958-62, Jean Dausset et al., Human leukocyte antigens • 1959-62, Rodney Porter et al., Discovery of antibody structure • 1959, James Gowans, Lympocyte circulation...
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