(unifocul eosinophilic granuloma)
The term “eosinophilic granuloma of bone” was introduced by Lichtenstein and Jaffe in 1940, although the lesion to which it referred had been described by others before them. The term used to describe a lesion of bone which is primarily a histiocytic proliferation, with an abindance of eosinophilic leukocytes but no intercellular lipid accumulation. This disease occurs primarily in older children and young adults, and the proportion of male to female is about two to one. Clinica Features Clinically, the lesion may present no physical signs or symptoms and may be found only upon an incidental roentgeno graphic examination of the bones of the head and other areas. On the other hand, there may be local pain, swelling and tenderness. The tissues of the mouth, sp that the different diagnosis between eosinophilic granuloma and some form of dental disease becomes imperative. Although the skull and mandible are common sites of involvement, the femur, humerus ribs, and other bones may also be affected. General malaise and fever occasionally account the eosinophilic granuloma of bone. Entgenographic Features The lesions appear as irregular radiolucent areas usually in superfacial alveolar bone. Cortex is often destroyed and pathologic cures may occur. If the lesions are in the… they usually appear as single or multiple… of refraction which may be so well cir-… …ribed as to resemble cysts of the jaw, typical granulomas or even periodontal disease. Pathologic Features microscopically, the primary cell is the histiocyte, which… in sheets or sheetlike collections. The …cytes may coalesce and form multinucle-giant cell, but this is quite uncommon. Early lesions also contain large numbers of collections of eosinophils. When the lesion matures, fibrosis occurs. In these older lesions the eosinophilis become less numerous, and they may even disappear so that the lesion approximates the histologic picture of...
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