Research on Hemophilia

Topics: Coagulation, Blood, Haemophilia B Pages: 19 (5295 words) Published: January 29, 2013
University of Santo Tomas High School
España, Manila

In partial fulfillment of the requirements in English 4

This library paper:

is submitted by





FEBRUARY 17, 2012


It is a great opportunity for me to write about this subject entitled “Hemophilia”. When I was preparing this research paper, I have gone through various books, articles, and websites which I believe can help me to get acquainted with new topics. I am focusing on those topics which are important for us to understand about this subject much better.

I acknowledge with great pride and honor to Mrs. Maria Teresa C. Ramos, my enthusiastic teacher, who has always been very understanding in helping and guiding me understand the various systems of my research paper.

Apart from me this research paper will certainly be boundless important for those who are interested to know more about this subject. I hope they will find it coherent.

I have tried my best to gather all similar documents regarding this subject. Furthermore, I don’t claim all the information in this research paper is included perfectly. There may be several vague ideas and false information, which are all mine and I am solely responsible for those but I will try to give a better version next time.

Thank You,
Jacques Ivan Arroyo


Chapter 1 – Introduction ---------------------------------------------------

Chapter 2 – Method ---------------------------------------------------------

Chapter 3 – Related Readings --------------------------------------------

Chapter 4 – Propositions --------------------------------------------------

Chapter 5 – Conclusion ----------------------------------------------------

Chapter 1


The word Hemophilia is derived from two Greek words haima, blood, and philein, to love – and, despite being senseless in the description of excess bleeding, it remains in general use. In the older literature various names have been used, e.g. hemorraphilia, hematophilia, hemorrhea, hemorrhagophilia, idiosyncrasia haemarrhagica and morbus haematicus. This first use of the world ‘hemophilia’ is attributed to Schonlein, who gave a dissertation entitled Die Hamophiliet at Wurzburg in 1828.

The disease is now called haemophilia A or classic haemophilia and is due to deficient activity of antihemophilic factor (AHF, antihemophilic globulin (AHG) or factor VIII. A variety has been described which is called Christmas disease in the UK but in Europe and the USA is often called haemophilia B or plasma thromboplastin component (PTC) deficiency. This is due to deficient activity of Christmas factor (CF, PTC or factor IX).

The clinical manifestations of these two diseases are essentially similar and no differentiation is made between them with regard to bleeding tendency. It is probable that genetically determined bleeding disorders are as old as time but they seem to have been neglected by the Egyptian, Romans and Greek physicians. The earliest documented case of a familial bleeding disorder occurs in the fourth-century Talmud and in Rabbinic writings thereafter.

Perhaps the most famous hemophilic family internationally is that of Queen Victoria, who in 1853 gave birth to her eighth child, Leopold, Duke of Albany, and he was a haemophiliac. In addition to this, two of her daughters proved to be carriers. It can truly be said that the result of the transmission of haemophilia into the royal families of Europe had a profound effect on the course of European history. Nowhere is this more poignant than in the case of Alexandra, who became the consort of Tsar Nicholas the Second of Russia, who produced Alexis, a severely affected haemophiliac, in 1904. In Victoria’s family there was no evidence of any ancestor with hemophilia and it must be presumed that the disease was due to mutant gene.



Bibliography: Howard, M. (2002). Hematology. United Kingdom: Harcourt Press.
Waterbury, L. (1996). Hematology. USA: Vicks.
Forbes, C.D. (1997). HEMOPHILIA. UK: Alden Press Ltd.
Aledort, L. (1997). HEMOPHILIA. London: Chapman & Hall.
Li, S. (2008). Electroporation Protocols Preclinical and Clinical Medicine. Totowa,
New Jersey: Humana Press.
Tefferi, A. (2001). Primary Hematology. Totowa, New Jersey: Humana Press.
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