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Relationship Between Nicotine And Baclofen

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Relationship Between Nicotine And Baclofen
4.3. Interactions between nicotine and baclofen

Activation of nAChRs within different areas of brain enhances release of several neurotransmitters including: glutamate,dopamine,norepinephrine, serotonin, ,gamma amino butyric acid(Wonnacott, 1997), (Benowitz, 2008) The regulation of releasing these neurotransmitters which is induced by nicotine`s effects depending on various postsynaptic receptors, is the usual mechanism by which nicotine modulates behavior (Benowitz, 2008).As we mentioned above activation of GABA B receptors in VTA block DA releasing in NAc(Koob, 1992; Mueller and Brodie, 1989; Xi and Stein, 1998)
In addition previous studies provide clear evidence for involvement of GABAB receptors agonist baclofen in decreases the withdrawl
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