Physioex Endocrine System

Topics: Hormone, Hypothalamus, Diabetes mellitus Pages: 7 (1717 words) Published: August 29, 2013
Lab 1 – Exercise 4: Endocrine SystemName: Kathryn Marso

ACTIVITY 1: Metabolism and Thyroid Hormone

Part 1:

Chart 1: Effects of Hormones on Metabolic Rate|
| Normal Rat| Thyroidectomized Rat| Hypophysectomized Rat| BaselineWeightMl O2 used in 1 minuteMl O2 used per hourMetabolic ratePalpation results| 250.9 grams 7.1 ml 426 ml 1697 ml O2/kg/hr| 245.7 grams 6.2 ml 372 ml 1514 ml O2/kg/hr| 244.6 grams 6.1 ml 366 ml 1496 ml O2/kg/hr| With thyroxineWeightMl O2 used in 1 minuteMl O2 used per hourMetabolic ratePalpation results| 249.5 grams 7.9 ml474 ml1899 ml O2/kg/hr| 245.9 grams 7.5 ml450 ml 1830 ml O2/kg/hr| 244.6 grams 7.5 ml 450 ml 1839 ml O2/kg/hr| With TSHWeightMl O2 used in 1 minuteMl O2 used per hourMetabolic ratePalpation results| 249. 8 grams 7.8 ml468 ml1873 ml O2/kg/hr| 245.7 grams 6.2 ml 372 ml 1514 ml O2/kg/hr| 245.2 grams 7.4 ml 444 ml 1810 ml O2/kg/hr| With propylthiouracil WeightMl O2 used in 1 minuteMl O2 used per hourMetabolic ratePalpation results| 250.8 grams 6.2 ml 372 ml 1483 ml O2/kg/hr| 244.0 grams 6.1 ml 366 ml 1500 ml O2/kg/hr| 244.6 grams 6.0 ml 360 ml 1471 ml O2/kg/hr|

1) Which rat had the fastest baseline metabolic rate?
Normal Rat

2) Why did the metabolic rates differ between the normal rat and the surgically altered rats? How well did the results compare with your prediction? They differed because the other two rats are missing the thyroid-stimulating hormone. This means the altered rats had either the thyroid or pituitary gland surgically removed, which is an important part in raising or lowering the hormone secretion.

3) If an animal has been thyroidectomized, what hormone(s) would be missing in its blood? Thyroxine.

4) If an animal has been hypophysectomized, what effect would you expect to see in the hormone levels in the body? The hormone levels would be lower than expected.

Part 2:

Chart 2.1: Glucose Standard Curve Results|
Tube| Optical density| Glucose (mg/dl)|
1| .30| 30|
2| .50| 60|
3| .60| 90|
4| .80| 120|
5| 1.00| 150|

Chart 2.2: Fasting Plasma Glucose Results|
Tube| Optical density| Glucose (mg/dl)|
1| 0.69| 99|
2| 0.81| 117|
3| 0.90| 134|
4| 0.80| 117|
5| 0.94| 140|

5) What was the effect of thyroxine injections on the normal rat’s BMR? The thyroxine injection caused the normal rat’s BMR to increase.

6) What was the effect of thyroxine injections on the thyroidectomized rat’s BMR? How does the BMR in this case compare with the normal rat’s BMR? Was the dose of thyroxine in the syringe too large or too small, or just right? The thyroxine injections on the thryoidectomized rat caused the BMR to increase. The BMR of the throidectomized rat with the thyroxine injections is slightly lower than the normal rat’s BMR with the injection. The dose was too large.

7) What was the effect of thyroxine injections on hypophysectomized rat’s BMR? How does the BMR in this case compare with the normal rat’s BMR? Was the dose of thyroxine in the syringe too large or too small, or just right? The hypophysectomized rat’s BMR with the thyroxine injection was also increased. Compared to the normal rat’s BMR, the hypophysectomized rat’s BMR is slightly lower. The dose of thyroxine in the syringe was too large.

Part 3:

Chart 3: Hormone Replacement Therapy Results|
Rat| T score|
Control| -2.6|
Estrogen...
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