Natural Killer Cells: A Case Study
The antibacterial activity of natural killer cells.
Introduction
Natural killer (NK) cells, a variety of granular lymphocyte, are the first line of defence against infections and cancer. First identified by their ability to “naturally” kill tumour cells previously unrecognised by the host (Kiessling et al., 1975), these bone marrow-derived innate killers were later recognised as a sepa-rate lymphocyte lineage, obtaining both cytotoxicity and cytokine-producing effector functions (Trinchi-eri, 1989). NK cells circulate and patrol the blood system and are activated via cytokine signalling or up-on encountering target cells that express NK cell receptor ligands (Lanier, 2005). Lytic activity subse-quently proceeds against the infected or altered host cell (Gonzales et al., 2012). There are …show more content…
and Melgar, S. (2012) Natural killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentium. Infection and Im-munity. 81(2): 460-9.
Humann, J. and Lenz, L. (2010) Activation of naive NK cells in re-sponse to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. Journal of Immunology. 184: 5172-78.
Igarashi, T., Wynberg, J., Srinivasan, R., Becknell, B., McCoy, J., Takahashi, Y., Suffredini, D., Linehan, M., Ca-ligiuri, M. and Childs, R. (2004) Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells. Journal of the American Society of Haematology. 104: 170-7.
Kiessling, R., Klein, E. and Wigzell, H. (1975) "Natural" killer cells in the mouse. I. Cytotoxic cells with specifici-ty for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur. J. Immunol. 5(2): 112-7.
Korbel, D., Finney, O. and Riley, E. (2004) Natural killer cells and innate immunity to protozoan pathogens. Int. J. Parasitol. 34:
Introduction
Natural killer (NK) cells, a variety of granular lymphocyte, are the first line of defence against infections and cancer. First identified by their ability to “naturally” kill tumour cells previously unrecognised by the host (Kiessling et al., 1975), these bone marrow-derived innate killers were later recognised as a sepa-rate lymphocyte lineage, obtaining both cytotoxicity and cytokine-producing effector functions (Trinchi-eri, 1989). NK cells circulate and patrol the blood system and are activated via cytokine signalling or up-on encountering target cells that express NK cell receptor ligands (Lanier, 2005). Lytic activity subse-quently proceeds against the infected or altered host cell (Gonzales et al., 2012). There are …show more content…
and Melgar, S. (2012) Natural killer cells protect against mucosal and systemic infection with the enteric pathogen Citrobacter rodentium. Infection and Im-munity. 81(2): 460-9.
Humann, J. and Lenz, L. (2010) Activation of naive NK cells in re-sponse to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. Journal of Immunology. 184: 5172-78.
Igarashi, T., Wynberg, J., Srinivasan, R., Becknell, B., McCoy, J., Takahashi, Y., Suffredini, D., Linehan, M., Ca-ligiuri, M. and Childs, R. (2004) Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells. Journal of the American Society of Haematology. 104: 170-7.
Kiessling, R., Klein, E. and Wigzell, H. (1975) "Natural" killer cells in the mouse. I. Cytotoxic cells with specifici-ty for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur. J. Immunol. 5(2): 112-7.
Korbel, D., Finney, O. and Riley, E. (2004) Natural killer cells and innate immunity to protozoan pathogens. Int. J. Parasitol. 34: