Heatopoietic Disorders: A Case Study
Anemia
Anemia is a common hematopoietic disorder in which a patient has a reduction in the total number of red blood cells and hemoglobin. The causes of anemia are decreased production of erythrocytes or blood loss, and increased destruction of erythrocytes (Huether & McCance, 2012). Anemia is classified into several types namely, pernicious anemia, folate deficiency anemia, sideroblastic anemia, chronic inflammatory anemia, and post-hemorrhagic anemia. For the purpose of this paper, I will select and discuss pernicious anemia.
Pathophysiology of Iron deficiency
Iron is required for the formation of hemoglobin and myoglobin in the body. Adult male experiencing bleeding maybe from an ulcer or hemorrhoid may lose approximately 1 to 1.5 mg of iron a day in feces, desquamated mucosal and skin cells likewise a menorrhagia female. The heme from destroyed erythrocytes is reprocessed back into new red blood cell. In the duodenum and upper jejunum is where Iron is mostly absorbed, is transported by transferrin and kept in either ferritin or hemosiderin forms. If more iron is lost or needed than can be absorbed, iron stores are used up, and the patient becomes iron deficient. Poor iron stores result in hemoglobin synthesis impairment. Anemia then results in reduced oxygen-carrying capacity and the resultant symptoms of fatigue, weakness, and dyspnea on …show more content…
Vitamin B- 12 is essential for DNA synthesis in erythrocytes and nuclear maturation. Therefore, when intrinsic factor is unable to bind with vitamin B-12, it will result to pepsin and IF deficiency causing pernicious anemia (Huether & McCance, 2012). Iron deficiency anemia and pernicious anemia are similar in terms occurrence per gender. It affects African American female in their childbearing age ( Huether & McCance,
Anemia is a common hematopoietic disorder in which a patient has a reduction in the total number of red blood cells and hemoglobin. The causes of anemia are decreased production of erythrocytes or blood loss, and increased destruction of erythrocytes (Huether & McCance, 2012). Anemia is classified into several types namely, pernicious anemia, folate deficiency anemia, sideroblastic anemia, chronic inflammatory anemia, and post-hemorrhagic anemia. For the purpose of this paper, I will select and discuss pernicious anemia.
Pathophysiology of Iron deficiency
Iron is required for the formation of hemoglobin and myoglobin in the body. Adult male experiencing bleeding maybe from an ulcer or hemorrhoid may lose approximately 1 to 1.5 mg of iron a day in feces, desquamated mucosal and skin cells likewise a menorrhagia female. The heme from destroyed erythrocytes is reprocessed back into new red blood cell. In the duodenum and upper jejunum is where Iron is mostly absorbed, is transported by transferrin and kept in either ferritin or hemosiderin forms. If more iron is lost or needed than can be absorbed, iron stores are used up, and the patient becomes iron deficient. Poor iron stores result in hemoglobin synthesis impairment. Anemia then results in reduced oxygen-carrying capacity and the resultant symptoms of fatigue, weakness, and dyspnea on …show more content…
Vitamin B- 12 is essential for DNA synthesis in erythrocytes and nuclear maturation. Therefore, when intrinsic factor is unable to bind with vitamin B-12, it will result to pepsin and IF deficiency causing pernicious anemia (Huether & McCance, 2012). Iron deficiency anemia and pernicious anemia are similar in terms occurrence per gender. It affects African American female in their childbearing age ( Huether & McCance,