The set up is kind of slow, yet story-building. Seeing as this is the last movie of the Blade saga, the script becomes more intense that the two prior. A band of vampires finally stumble upon a diamond when they discover the remains of the legendary Dracula in a cave in the middle of the Iraqi Desert. When they reach his body which was buried deep underground they come to realize he is still alive.
In a chase with some "familiars" as Blade calls them, he rams the back of the car with his vintage Black Mustang and causes the car to hydroplane and flip over. The other passengers ash, as the one in the back seat tries to make a break for it. Silver stakes rounds fired off by Blade's sawed off shotgun echo through the air. He's been set up, the target was human. He runs off into the darkness retreating to his hideout where Whistler is.
Whistler, Blade's "partner in crime" and also longtime father figure dies in a shootout with the SWAT Team who stealthily followed Blade back. Blade attempts to make an escape, but to no avail. While incarcerated, Hannibal King, the best friend of Abby, Whistler's daughter, breaks in and rescues Blade.
They later share the details of what exactly is happening and brings Blade up to speed about Dracula and what is being planned. How the vampires started a blood bank and potentially will run the country if they don't act soon enough.
One evening, Dracula mauls Heather, Whistler's eldest daughter, who is also blind, killing her. However, her death did serve purpose, she had been working on a cure to kill all vampires by killing Dracula. Accompanied by Whistler's youngest daughter, Abby and her best friend King, they both help Blade attempt to put an end to the massacre Dracula has begun to start.
As the story climaxes, Blade and Dracula duke it out in a sword fight which is a battle literally to the death. While fencing, Abby shoots an arrow filled with the vaccine but misses. This is corny because are...
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