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Crohn's Disease Ulcerative Colitis: A Case Study

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Crohn's Disease Ulcerative Colitis: A Case Study
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Genetic Susceptibility

• Different genetic abnormalities can lead to similar disease phenotypes. • Genes associated with Crohn's disease are not implicated in Ulcerative Colitis • There is similar chromosomal susceptibility in CD and UC.

Crohn’s disease Ulcerative Colitis

Mutant CARD15 causes; Decreased antimicrobial peptide secretions from Paneth cells of the small intestine Defective down-regulation of innate immune response to bacterial adjuvants Ineffective clearance of intra- cellular bacteria infections Proliferation of luminal and mucosally adherent commensal bacteria …show more content…
o Adjuvants activate innate immune responses, including dendritic cells and other APCs o Antigens stimulate the clonal expansion of T cells that selectively recognize the antigen through their T-cell receptor leading to aggravated T-cell response • There is both bacterial and host specificity to each disease

Crohn’s disease Ulcerative Colitis

Luminal Microbial Antigens and Adjuvants

• Infection and NSAIDS -Initiate non-specific inflammation and break mucosal barrier • Diet - Implicated by patients but mechanisms poorly understood • Aluminium and Iron may have adjuvant activity and
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